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 Χμ’¨Žq‚̋ƐѠ/ Publication


‘ Œ΄’˜˜_•Ά / Original articles


  1. Hosokawa N, Tremblay LO, Sleno B, Kamiya Y, Wada I, Kato K, Nagata K, and Herscovics A.   EDEM1 accelerates the trimming of ƒΏ1,2-linked mannose on the C branch of N-glycans.   Glycobiology: in press(2010)


  2. Hosokawa N, Kamiya Y, Kamiya D, Kato K, and Nagata K.   Human OS-9, alectin required for glycoprotein endoplasmic reticulum-associated degradation, recognizes mannose-trimmed N-glycans.   J Biol Chem. : 28417061-17068(2009)


  3. Hosokawa N, Wada I, Nagasawa K, Moriyama T, Okawa K, Nagata K.   Human XTP3-B Forms an Endoplasmic Reticulum Quality Control Scaffold with the HRD1-SEL1L Ubiquitin Ligase Complex and BiP.   J Biol Chem. : 283(30):20914-24(2008)


  4. Morito D, Hirao K, Oda Y, Hosokawa N, Tokunaga F, Cyr DM, Tanaka K, Iwai K, Nagata K.   Gp78 cooperates with RMA1 in ER-associated degradation of CFTRƒ’F508   Mol. Biol. Cell.: 19,1328-1336(2008)


  5. Hosokawa N, You Z, Tremblay L O, Nagata K, Herscovics A.   Stimulation of ERAD of misfolded null Hong Kong ƒΏ1-antitrypsin by Golgi ƒΏ1,2-mannosidases.   Biochem. Biophys. Res. Commun. : 362, 626-632(2007)


  6. Nagasawa K, Higashi T, Hosokawa N, Kaufman R J, Nagata K.   Simultaneous induction of the four subunits of TRAP complex by ER stress accelerates ER degradation.   EMBO Rep. : 8, 483-489(2007)


  7. Hirao K, Natsuka Y, Tamura T, Wada I, Morito D, Natsuka S, Romero P, Sleno B, Tremblay L O, Herscovics A, Nagata K, Hosokawa N.   EDEM3, a soluble EDEM homolog, enhances glycoprotein endoplasmic reticulum-associated degradation and mannose trimming.   J. Biol. Chem. : 281, 9650-9658 (2006)


  8. Hosokawa N, Wada I, Natsuka Y, Nagata K.   EDEM accelerates ERAD by preventing aberrant dimer formation of misfolded ƒΏ1-antitrypsin.   Genes to Cells : 11, 465-476 (2006)


  9. Kano F, Kondo H, Yamamoto A, Kaneko Y, Uchiyama K, Hosokawa N, Nagata K, Murata M. NSF/SNAPs and p97/p47/VCIP135 are sequentially required for cell cycle-dependent reformation of the ER network. Genes to Cells : 10, 989-999 (2005)


  10. Kano F, Kondo H, Yamamoto A, Tanaka A R, Hosokawa N, Nagata K, Murata M. The maintenance of the endoplasmic reticulum network is regulated by p47, a cofactor of p97, through phosphorylation by cdc2 kinase. Genes to Cells : 10, 333-344 (2005)


  11. Matsuoka Y, Kubota H, Adachi E, Nagai N, Marutani T, Hosokawa N, Nagata K. Abnormal basement membrane-like structure in embryoid bodies derived from Hsp-47-null embryonic stem cells. Molec. Biol. Cell : 15, 4467-4475 (2004)


  12. Hosokawa N, Tremblay L O, You Z, Herscovics A, Wada I, Nagata K. Enhancement of endoplasmic reticulum (ER) degradation of misfolded null Hong Kong a1-antitrypsin by human ER mannosidase I. J. Biol. Chem. : 278, 26287-26294 (2003)


  13. Yoshida H, Matsui T, Hosokawa N, Kaufman R J, Nagata K, Mori K. A time-dependent phase shift in the mammalian unfolded protein response. Dev. Cell :4, 265-271 (2003)


  14. Oda Y, Hosokawa N, Wada I, Nagata K. EDEM as an acceptor of terminally misfolded glycoproteins released by calnexin. Science : 299, 1394-1397 (2003)


  15. Yasuda K, Hirayoshi K, Hirata H, Kubota H, Hosokawa N, Nagata K. The Kruppel-like factor Zf9 and proteins in the Sp1 family regulate the expression of HSP47, a collagen-specific molecular chhaperone. J. Biol. Chem. : 277, 44613-44622 (2002)


  16. Sato K, Yomogida K, Yorihuzi T, Nishimune Y, Hosokawa N, Nagata K. Type XXVI collagen, a new member of the collagen family, is specifically expressed in the testis and ovary. J. Biol. Chem. : 277, 37678-37684 (2002)


  17. Hosokawa N, Wada I, Hasegawa K, Yorihuzi T, Tremblay L O, Herscovics A, Nagata K. A novel ER a-mannosidase-like protein accelerates ER-associated degradation. EMBO Reports : 2, 415-422 (2001)


  18. Naitoh M, Hosokawa N, Kubota H, Tanaka T, Shirane H, Sawada M, Nishimura Y, Nagata K. Upregulation of HSP47 and collagen type III in the dermal fibrotic disease, keloid. Biochem. Biophys. Res. Commun. : 280, 1316-1322 (2001)


  19. Murakami Y, Toda T, Seiki T, Munetomi E, Kondo Y, Sakurai T, Fukukawa Y, Natsuyama M, Nagate T, Hosokawa N, Nagata K. Heat shock protein (HSP) 47 and collagen are upregulated during neointimal formation in the baloon-injured rat carotid artery. Atherosclerosis : 157, 361-368 (2001)


  20. Matsuda M, Koide T, Yorihuzi T, Hosokawa N, Nagata K. Molecular cloning of a novel ubiquitin-like protein, UBIN, that binds to ER targeting singal sequences. Biochem. Biophys. Res. Commun. : 280, 535-540 (2001)


  21. Nakatsukasa K, Nishikawa S-i, Hosokawa N, Nagata K, Endo T. Mnl1p, an a-mannosidase-like protein in yeast Saccharomyces cerevisiae, is required for ER associated degradation of glycoproteins. J. Biol. Chem. : 276, 8635-8638 (2001)


  22. Hosokawa N, Wada I, Hasegawa K, Yorihuzi T, Tremblay L O, Herscovics A, Nagata K. A novel ER a-mannosidase-like protein accelerates ER-associated degradation. EMBO Reports : 2, 415-422 (2001)


  23. Nagai N, Hosokawa M, Itohara S, Adachi E, Matsushita T, Hosokawa N, Nagata K. Embryonic lethality of molecular chaperone Hsp47 knockout mice is associated with defects in collagen biosynthesis. J. Cell Biol. : 150, 1499-1505 (2000)


  24. Hosokawa N, Nagata K. Procollagen binds to both prolyl 4-hydrxylase/protein disulfide isomerase and HSP47 within the endoplasmic reticulum in the absence of ascorbate. FEBS Lett. : 466, 19-25 (2000)


  25. Hirata H, Yamamura I, Yasuda K, Kobayashi A, Tada H, Suzuki M, Hirayoshi K, Hosokawa N, Nagata K. Separate cis-acting DNA elements control cell type- and tissue-specific expression of collagen-binding molecular chaperone HSP47. J. Biol. Chem. : 274, 35703-35710 (1999)


  26. Nagai N, Yorihuzi T, Hosokawa N, Nagata K. The human genome has only one functional hsp47 gene (CBP2) and pseudogene (pshsp47). Gene : 227, 241-248 (1999)


  27. Masuda H, Hosokawa N, Nagata K. Expression and localization of collagen-binding stress protin Hsp47 in mouse embryo developement: comparison with types I and II collagen. Cell Stress & Chaperones : 3, 256-264 (1998)


  28. Yamamura I, Hirata H, Hosokawa N, Nagata K. Transcriptional activation of the mouse HSP47 gene in mouse osteoblast MC3T3-E1 cells by TGF-beta 1. Biochem. Biophys. Res. Commun. : 244, 68-74 (1998)


  29. Hosokawa N, Hohenadl C, Satoh M, Kuhn K, Nagata K. HSP47, a collagen-specific molecular chaperone, delays the secretion of type III procollagen transfected in human embryonic kidney cell line 293. A possible role for HSP47 in collagen modification. J. Biochem. :124, 654-662 (1998)


  30. Satoh M, Hirayoshi K, Yokota S, Hosokawa N, Nagata K. Intracellular Interaction of collagen-specific stress protein HSP47 with newly synthesized procollagen. J. Cell Biol. : 133, 469-483 (1996)


  31. Takechi H, Hosokawa N, Hirayoshi K, Nagata K. Alternative 5' splice site selection induced by heat shock. Mol. Cell. Biol. : 14, 567-575 (1994)


  32. Hosokawa N, Takechi H, Yokota S, Hirayoshi K, Nagata K. Structure of the gene encoding the mouse 47-kDa heat shock protein (HSP47). Gene : 126, 187-193 (1993)


  33. Koishi M, Hosokawa N, Sato M, Nakai A, Hirayoshi K, Hiraoka M, Nagata K. Quercetin, an inhibitor of heat shock protein synthesis, inhibits the acquisition of thermotolerance in a human colon carcinoma cell line. Jpn. J. Cancer Res. : 83, 1216-1222 (1992)


  34. Kioka N, Hosokawa N, Komano T, Hirayoshi K, Nagata K, Ueda K. Quercetin, a bioflavonoid, inhibits the increase of human multidrug resistance gene (MDR1) expression caused by arsenite. FEBS Lett.: 301, 307-309 (1992)


  35. Hosokawa N, Hirayoshi K, Kudo H, Takechi H, Aoike A, Kawai K, Nagata K. Inhibition of the activation of heat shock factor in vivo and in vitro by flavonoids. Mol. Cell. Biol. : 12, 3490-3498 (1992)


  36. Marui N, Sakai T, Hosokawa N, Yoshida M, Aoike A, Kawai K, Nishino H, Fukushima M. N-myc suppression and cell cycle arrest at G1 phase by prostaglandins. FEBS Lett. : 270, 15-18 (1990)


  37. Yoshida M, Sakai T, Hosokawa N, Marui N, Matsumoto K, Fujioka A, Nishino H, Aoike A. The effect of quercetin on cell cycle progression and growth of human gastric cancer cells. FEBS Lett. : 260, 10-13 (1990)


  38. Hosokawa N, Hirayoshi K, Nakai A, Hosokawa Y, Marui N, Yoshida M, Sakai T, Nishino H, Aoike A, Kawai K, Nagata K. Flavonoids inhibits the expression of heat shock proteins. Cell Struct. Funct. : 15, 393-401 (1990)


  39. Hosokawa N, Hosokawa Y, Sakai T, Yoshida M, Marui N, Nishino H, Kawai K, Aoike A. Inhibitory effect of quercetin on the synthesis of a possibly cell-cycle-related 17-kDa protein in human colon cancer cells. Int. J. Cancer : 45, 1119-1124 (1990)


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