安達 泰治

京都大学 再生医科学研究所 ナノ再生医工学研究センター
バイオメカニクス研究領域 教授

〒606-8507 京都市左京区聖護院川原町町53
adachifrontier.kyoto-u.ac.jp

Research Interests

  • Biomechanics / Mechanobiology
  • Computational Mechanics

My research activities originally have been focused on the computational biomechanics of functional adaptation by remodeling in bone that has mechanical hierarchy in structure-function relationships from the macroscopic organ/tissues levels to the microscopic cell/molecular levels. In the last decade, we have been working on the response of bone cells such as osteoblasts and osteocytes to the mechanical stimulus through in vitro experiments. In bone adaptation, the mechanism at cellular and molecular levels, by which local mechanical cue is sensed by cells and the systems remodel their structure to meet functional demands, remains unclear. To approach this issue, we went down the stairs to more cellular and molecular levels, and we have been conducting modeling and simulation of the cell that consists of cytoskeletal structures to explore the multiscale biomechanical phenomena in the cellular system including cell migration and mechanosensing. These studies have been combined with in vitro experiments on the actin dynamics and on the measurements of the interactions between actin filaments and their binding proteins using atomic force microscopy. Specially, we focus on the interactions between mechanical and biochemical factors that are essential for the dynamical cellular activities.


Degrees

  • B.S.: Mechanical Engineering, Kobe University, Kobe, Japan, March, 1990
  • M.S.: Mechanical Engineering, Osaka University, Osaka, Japan, March, 1992
  • Ph.D.: Mechanical Engineering, Osaka University, Osaka, Japan, February, 1997


Professional Experience

  • 1992. 4 - 1998. 3: Research Associate, Department of Mechanical Engineering, Kobe University
  • 1998. 4 - 2004. 3: Associate Professor, Department of Mechanical Engineering, Kobe University
  • 2004. 4 - 2005. 3: Associate Professor, Department of Mechanical Engineering, Kyoto University
  • 2005. 4 - 2010. 3: Associate Professor, Department of Mechanical Engineering and Science, Kyoto University
  • 2010. 4 -9999.99: Professor, Department of Biomechanics, Research Center for Nano Medical Engineering, Institute for Frontier Medical Sciences, Kyoto University
  • 2012. 4 -9999.99: Director, Research Center for Nano Medical Engineering, Institute for Frontier Medical Sciences, Kyoto University
  • 2013. 4 -9999.99: Associate Director, Institute for Frontier Medical Sciences, Kyoto University

  • 1997.10 - 1999. 3: Research Fellow, Orthopaedic Research Laboratories, Department of Surgery, The University of Michigan
  • 1998. 4 - 1999. 3: Research Fellow, Japan Society for the Promotion of Science
  • 1999. 6 - : Visiting Research Fellow, Computational Biomechanics Unit, The Institute of Physical and Chemical Research (RIKEN)
  • 2000. 4 - 2001. 3: Visiting Professor, Department of Mechanical Engineering, Faculty of Engineering, Okayama University
  • 2002. 4 - 2002. 9: Visiting Professor, Department of Mechanical Engineering, Graduate School of Engineering, Nagoya University
  • 2003.10 - 2004. 3: Visiting Professor, Department of Mechanical Engineering, Graduate School of Engineering, Kyoto University
  • 2006. 4 - 2011. 3: Team Leader, Computational Cell Biomechanics Team, VCAD System Research Program, Center for Intellectual Property Programs and Managements, The Institute of Physical and Chemical Research (RIKEN)


Awards

1995.12 : Seguchi Frontier Award, NCP
1998. 4 : Young Engineers Award, Japan Society of Mechanical Engineers
2000. 1 : Seguchi Prize, Division of Bioengineering, Japan Society of Mechanical Engineers
2001. 5 : Young Researchers Award, Japanese Society for Medical and Biological Engineering
2001.12 : Best Presentation Award, Materials and Mechanics Division,
　Japan Society of Mechanical Engineers
2002. 4 : JSME Medal for Outstanding Paper, Japan Society of Mechanical Engineers
2002. 5 : The Most Interesting Reading Award, Japan Society for Design Engineering
2003. 9 : Best Research Award, Biomedical Engineering Symposium,
　Japanese Society for Medical and Biological Engineering
2005.12 : JACM Award for Young Investigators in Computational Mechanics,
　Japan Association for Computational Mechanics
2006.11 : Young Investigator Award, Japanese Society for Clinical Biomechanics
2007.12 : APACM Award for Young Investigator in Computational Mechanics,
　(Asian Pacific Association for Computational Mechanics)
2008. 4 : JSME Medal for Outstanding Paper, Japan Society of Mechanical Engineers
2011. 11 : 2011 JBSE Paper of the Year, Journal of Biomechanical Science and Engineering
2011. 11 : 2011 JBSE Graphics of the Year, Journal of Biomechanical Science and Engineering


Editorial Boards

2013. 4- : Associate Editor, In Silico Cell and Tissue Science
2010.11- : Editorial Board, Molecular & Cellular Biomechanics
2009. 8- : Editorial Board (Consulting Editor), Journal of Biomechanics
2009. 2- : Editorial Board, Computer Methods in Biomechanics and Biomedical Engineering
2008. 3- : Editorial Board, Journal of the Mechanical Behavior of Biomedical Materials
2010. 4- : Associate Editor, Journal of Biomechanical Science and Engineering
2006. 1-2010. 3 : Chief Editor, Journal of Biomechanical Science and Engineering
2005. 4-2007. 3 : Editor, JSME International Journal
2003.10-2011.12 : Editorial Board, International Journal of Mechanics and Materials in Design

Journal of Biomechanical Science and Engineering



Societies

20xx.__- : European Society of Biomechanics, Member
20xx.__- : Biophysical Society, Member
2008. 8- : World Council of Biomechanics, Council Member


Selected Publications

  • 12G__Finite Element Formulation and Analysis for an Arterial Wall with Residual and Active Stresses
    Naoki Kida, Taiji Adachi
    2014-___, Computer Methods in Biomechanics and Biomedical Engineering, (in press)
  • 12F) Numerical Analysis of Arterial Contraction Regulated by Deformation-dependent Intracellular Calcium Ion Concentration
    Naoki Kida, Taiji Adachi
    2014-___, Journal of Biomechanical Science and Engineering, (in press)
  • 12E) A Novel Osteblast/Osteocyte Selection Method in Primary Isolated Chick Bone Cells by Atomic Force Microscopy
    Sung-Woong Han, Takato Tamaki, and Taiji Adachi
    2014-___, Journal of Nanoscience and Nanotechnology, (in press)
  • 12D) Modeling Trabecular Bone Adaptation to Local Bending Load Regulated by Mechanosensing Osteocytes
    Yoshitaka Kameo, Taiji Adachi
    2014-___, Acta Mechanica, (in press)
  • 12C) Interstitial Fluid Flow in Canaliculi as a Mechanical Stimulus for Cancellous Bone Remodeling: In silico Validation
    Yoshitaka Kameo and Taiji Adachi
    2014-___, Biomechanics and Modeling in Mechanobiology, (in press) [Link].
  • 12B) A Novel Graphene Oxide-based Protein Interaction Measurement Using Atomic Force Microscopy
    Sung-Woong Han, Kyouhei Morita, Taiji Adachi
    2014-___, Journal of Nanoscience and Nanotechnology, (in press)
  • 12A) Probing Actin Filament and Binding Protein Interaction Using an Atomic Force Microscopy
    Sung-Woong Han, Kyohei Morita, Patriche Simona, Takanori Kihara, Jun Miyake, Mihaela Banu, Taiji Adachi
    2014-__, Journal of Nanoscience and Nanotechnology, (in press)

    - - - - -

  • J122) Single-Cell Manipulation and DNA Delivery Technology Using Atomic Force Microscopy and Nanoneedle Sung-Woong Han, Chikashi Nakamura, Jun Miyake, Sang-Mok Chang, and Taiji Adachi
    2014-1, Journal of Nanoscience and Nanotechnology, Vol. 14, No. 1, pp. 57-70. [Link].

  • 121) TAG-1-assisted Progenitor Elongation Streamlines Nuclear Migration to Optimize Subapical Crowding
    Mayumi Okamoto, Takashi Namba, Tomoyasu Shinoda, Takefumi Kondo, Tadashi Watanabe, Yasuhiro Inoue, Kosei Takeuchi, Yukiko Enomoto, Kumiko Ota, Kanako Oda, Yoshino Wada, Ken Sagou, Kanako Saito, Akira Sakakibara, Ayano Kawaguchi, Kazunori Nakajima, Taiji Adachi, Toshihiko Fujimori, Masahiro Ueda, Shigeo Hayashi, Kozo Kaibuchi, Takaki Miyata
    2013-11, Nature Neuroscience, Vol. 16, No. 11, pp. 1556-1566. [Link].
  • 120) External Mechanical Cues Trigger the Establishment of the Anterior-posterior Axis in Early Mouse Embryos
    Ryuji Hiramatsu, Toshiki Matsuoka, Chiharu Kimura-Yoshida, Sung-Woong Han, Kyoko Mochida, Taiji Adachi, Shunichi Takayama, Isao Matsuo
    2013-10, Developmental Cell, Vol. 27, No. 2, pp. 131-144. [Link].
  • 119) Modeling Cell Proliferation for Simulating Three-dimensional Tissue Morphogenesis Based on a Reversible Network Reconnection Framework
    Satoru Okuda, Yasuhiro Inoue, Mototsugu Eiraku, Yoshiki Sasai, Taiji Adachi
    2013-10, Biomechanics and Modeling in Mechanobiology, Vol. 12, No. 5, pp. 987-996. [Link].
  • 118) Three-dimensional Modulation of Cortical Plasticity during Pseudopodial Protrusion of Mouse Leukocytes
    Hiromi Miyoshi, Ken-ichi Tsubota, Takamasa Hoyano, Taiji Adachi, Hao Liu
    2013-9, Biochemical and Biophysical Research Communications, Vol. 438, pp. 594-599. [Link].
  • 117) Reversible Network Reconnection Model for Simulating Large Deformation in Dynamic Tissue Morphogenesis
    Satoru Okuda, Yasuhiro Inoue, Mototsugu Eiraku, Yoshiki Sasai, Taiji Adachi
    2013-8, Biomechanics and Modeling in Mechanobiology, Vol. 12, No. 4, pp. 627-644. [Link].
  • 116) Apical Contractility in Growing Epithelium Supports Robust Maintenance of Smooth Curvatures against Cell-division-induced Mechanical Disturbance
    Satoru Okuda, Yasuhiro Inoue, Mototsugu Eiraku, Yoshiki Sasai, Taiji Adachi
    2013-6, Journal of Biomechanics, Vol. 46, No. 10, pp. 1705-1713. [Link].
  • 115) Role of the Actin-myosin Catch Bond on Actomyosin Aggregate Formation
    Yasuhiro Inoue, Taiji Adachi
    2013-3, Cellular and Molecular Bioengineering, Vol. 6, No. 1, pp. 3-12.
    [Link].
  • 114) Real-time Monitoring of Changes in Microtubule Mechanical Properties in Response to Microtubule-destabilizing Drug Treatment
    Sung-Woong Han, Patriche Simona, Mihaela Banu, Taiji Adachi
    2013-3, Journal of Nanoscience and Nanotechnology, Vol. 13, No. 3, pp. 2087-2090. [Link]

  • 113) Microscale Fluid Flow Analysis in a Human Osteocyte Canaliculus Using a Realistic High-resolution Image-based Three-dimensional Model
    Hiroshi Kamioka, Yoshitaka Kameo, Yuichi Imai, Astrid D Bakker, Rommel G Bacabac, Naoko Yamada, Akio Takaoka, Takashi Yamashiro, Taiji Adachi, Jenneke Klein-Nulend
    2012-9, Integrative Biology, Vol. 4, No. 10, pp. 1198-1206. [Link].
  • 112) Spatiotemporal Coordinated Hierarchical Properties of Cellular Protrusion Revealed by Multiscale Analysis
    Hiromi Miyoshi, Taiji Adachi
    2012-7, Integractive Biology, Vol. 4, No. 8, pp. 875-888. [Link].
  • 111) Quantitative Analysis of Extension-torsion Coupling of Actin Filaments
    Shinji Matsushita, Yasuhiro Inoue, Taiji Adachi
    2012-4, Biochemical and Biophysical Research Communications, Vol. 420, No. 4, pp. 710-713. [Link].
  • 110) Roles of Heparan Sulfate Sulfation in Dentinogenesis
    Satoru Hayano, Hiroshi Kurosaka, Takeshi Yanagita, Ina Kalus, Fabian Milz, Yoshihito Ishihara, Md. Nurul Islam, Noriaki Kawanabe, Masahiro Saito, Hiroshi Kamioka, Taiji Adachi, Thomas Dierks, Takashi Yamashiro
    2012-4, Journal of Biological Chemistry, Vol. 287, No. 15, pp. 12217-12229. [Link].
  • 109) Multiscale Modeling and Mechanics of Filamentous Actin Cytoskeleton
    Hidetaka Yamaoka, Shinji Matsushita, Yoshitaka Shimada, Taiji Adachi
    2012-3, Biomechanics and Modeling in Mechanobiology, Vol. 11, No. 3/4, pp. 291-302. [Link].
  • 108) Interfacial Fatigue Crack Propagation in Microscopic Model Composite Using Bifiber Shear Specimens
    Masaki Hojo, Yukinobu Matsushita, Mototsugu Tanaka and Taiji Adachi
    2012-2, Composites Part A, Vol. 43, No. 2, pp. 239-245. [Link].
  • 107) Characteristics of Motility-based Filtering of Adherent Cells on Microgrooved Surfaces
    Hiromi Miyoshi, Taiji Adachi, Jungmyoung Ju, Sang Min Lee, Dong Jin Cho, Jong Soo Ko, Go Uchida, Yutaka Yamagata
    2012-1, Biomaterials, Vol. 33, No.2, pp. 395-401. [Link].

  • 106) Relaxation-Expansion Model for Self-Driven Optic-Cup Morphogenesis
    Mototsugu Eiraku, Taiji Adachi, Yoshiki Sasai
    2011-11, BioEssay, Vol. 34, pp. 17-25. [Link].
  • 105) Mode I Type Delamination Fracture Toughness of YBCO Coated Conductor with Additional Cu Layer
    Takafumi Miyazato, Masaki Hojo, Michinaka Sugano, Taiji Adachi, Yasuhiro Inoue, Koji Shikimachi, Naoki Hirano, Shigeo Nagaya
    2011-11, Physica C, Vol. 471, No. 21-22, pp. 1071-1074. [Link].
  • 104) Effect of Actomyosin Contractility on Lamellipodial Protrusion Dynamics on a Micropatterned Substrate
    Kennedy O. Okeyo, Masuzo Nagasaki, Junko Sunaga, Masaki Hojo, Hidetoshi Kotera, Taiji Adachi
    2011-9, Cellular and Molecular Bioengineering, Vol. 4, No. 3, pp. 389-398. [Link].
  • 103) Advances in Experiments and Modeling in Micro- and Nano-Biomechanics: A Mini Review
    Mian Long, Masaaki Sato, Chwee Teck Lim, Jianhua Wu, Taiji Adachi, Yasuhiro Inoue
    2011-9, Cellular and Molecular Bioengineering, Vol. 4, No. 3, pp. 327-339. [Link].
  • 102) Effects of Loading Frequency on Functional Adaptation of Trabecula Predicted by Bone Remodeling Simulation
    Yoshitaka Kameo, Taiji Adachi, Masaki Hojo
    2011-8, Journal of the Mechanical Behavior of Biomedical Materials, Vol. 4, No. 6, 900-908. [Link]
  • 101) A Novel Method for Measuring Tension Generated in Stress Fibers by Applying External Forces
    Shukei Sugita, Taiji Adachi, Yosuke Ueki, Masaaki Sato
    2011-7, Biophysical Journal, Vol. 101, No. 1, pp. 53-60. [Link]
  • 100) Coarse-grained Brownian Ratchet Model of Membrane Protrusion on Cellular Scale
    Yasuhiro Inoue, Taiji Adachi
    2011-7, Biomechanics and Modeling in Mechanobiology, Vol. 10, No. 4, pp. 495-503. [Link]
  • 99) Modeling Myosin-dependent Rearrangement and Force Generation in an Actomyosin Network
    Yasuhiro Inoue, Shunsuke Tsuda, Koji Nakagawa, Masaki Hojo, Taiji Adachi
    2011-7, Journal of Theoretical Biology, Vol. 281, No. 1, pp. 65-73. [Link]
  • 98) Effect of Tensile Force on the Mechanical Behaviour of Actin Filaments
    Shinji Matsushita, Yasuhiro Inoue, Masaki Hojo, Masahiro Sokabe, Taiji Adachi
    2011-6, Journal of Biomechanics, Vol. 44, No. 9, pp. 1776-1781. [Link]
  • 97) Self-organizing Optic-cup Morphogenesis in Three-dimensional Culture
    Mototsugu Eiraku, Nozomu Takata, Hiroki Ishibashi, Masako Kawada, Eriko Sakakura, Satoru Okuda, Kiyotoshi Sekiguchi, Taiji Adachi, Yoshiki Sasai
    2011-4, Nature, Vol. 472, pp. 51-56. [Link]
  • 96) Evaluation of a 3-D, Woven-fabric, Composite Scaffold Using Experimental Canine Models of Bone Defects in Mandibles
    Shunsuke Baba, Yoshiya Hahimoto, Takeomi Inoue, Daisuke Kimura, Saeko Sumikura, Yomi Sonoda, Yoichi Yamada, Kenji Ito, Masaki Hojo, Taiji Adachi
    2011-3, Journal of Oral Tissue Engineering, Vol. 8, No. 3, pp. 212-221. [Link]

  • 95) Application of Bioimaging to Osteocyte Biology
    Hiroshi Kamioka, Taiji Adachi
    2010-12, Clinical Reviews in Bone and Mineral Metabolism, Vol. 8, No. 4, pp. 170-178. [Link]
  • Evaluation of Extensional and Torsional Stiffness of Single Actin Filaments by Molecular Dynamics Analysis
    Shinji Matsushita, Taiji Adachi, Yasuhiro Inoue, Masaki Hojo and Masahiro Sokabe
    2010-12, Journal of Biomechanics, Vol. 43, No. 16, pp. 3162-3167. [Link]
  • Effectiveness of Scaffolds with Pre-seeded Mesenchymal Stem Cells in Bone Regeneration: Assessment of Osteogenic Ability of Scaffolds Implanted under the Periosteum of the Cranial Bone of Rats
    Shunsuke Baba, Takeomi Inoue, Yoshiya Hashimoto, Daisuke Kimura, Masatoshi Ueda, Kana Sakai, Naoyuki Matsumoto, Chiaki Hiwa, Taiji Adachi, Masaki Hojo
    2010-11, Dental Materials Journal, Vol. 29, No. 6, pp. 673-681. [Link]
  • Simulations of Dynamics of Actin Filaments by Remodeling Them in Shear Flows
    Yasuhiro Inoue, Takeji Deji, Yoshitaka Shimada, Masaki Hojo, Taiji Adachi
    2010-11/12, Computers in Biology and Medicine, Vol. 40, No. 11/12, pp. 876-882. [Link]
  • Control of Highly Migratory Cells by Microstructured Surface Based on Transient Change in Cell Behavior
    Hiromi Miyoshi, Jungmyoung Ju, Sang Min Lee, Dong Jin Cho, Jong Soo Ko, Yutaka Yamagata, Taiji Adachi
    2010-11, Biomaterials, Vol. 31, No. 33, pp. 8539-8545. [Link]
    + RIKEN Research Highlight: [Guided by the Groove]
  • Effect of Fatigue Loading on Critical Current in Stainless Steel-Laminated DI-BSCCO Superconducting Composite Tape
    Masaki Hojo, Kenta Osawa, Taiji Adachi, Yasuhiro Inoue, Kozo Osamura, Shojiro Ochiai, Naoki Ayai, Kazuhiko Hayashi
    2010-11, Physica C, Vol. 470, pp. 1373-1376. [Link]
  • Approach Behavior of Binding Proteins toward Actin Filament (Brownian Dynamics Simulation)
    Taiji Adachi, Yoshitaka Shimada, Yasuhiro Inoue, Masaki Hojo
    2010-8, Transactions of the Japan Society of Mechanical Engineers, Vol. 76, No. 8, pp. 1119-1127. (in Japanese) [Link]
  • Continuum Dynamics on a Vector Bundle for a Directed Medium
    Hidetaka Yamaoka and Taiji Adachi
    2010-7, Journal of Physics A: Mathematical and Theoretical, Vol. 43, No. 32, pp. 325209 (15pp). [Link]
  • Trabecular Bone Remodelling Simulation Considering Osteocytic Response to Fluid-induced Shear Stress
    Taiji Adachi, Yoshitaka Kameo, Masaki Hojo
    2010-5, Philosophical Transactions of the Royal Society A, Vol. 368, pp. 2669-2682. [Link]
  • Observation of Chondrocyte Aggregate Formation and Internal Structure on Micropatterned Fibroin-Coated Surface
    Naoyoshi D. Kachi, Akihisa Otaka, Seungwoo Sim, Yoshihiko Kuwana, Yasushi Tamada, Junko Sunaga, Taiji Adachi and Naohide Tomita
    2010-5, Bio-Medical Materials and Engineering, Vol. 20, No. 1, pp. 55-63. [Link]
  • Mechanical Regulation of Actin Network Dynamics in Migrating Cells
    Kennedy Omondi Okeyo, Taiji Adachi, Masaki Hojo
    2010-4, Journal of Biomechanical Science and Engineering, Vol. 5, No. 3, pp. 186-207. (Review Paper) [Link]
  • Estimation of Bone Permeability Considering Morphology of Lacuno-Canalicular Porosity
    Yoshitaka Kameo, Taiji Adachi, Narumichi Sato, Masaki Hojo
    2010-4, Journal of the Mechanical Behavior of Biomedical Materials, Vol. 3, No. 3, pp. 240-248. [Link]
  • Geometrical Range of Microscopic Stress Distribution Change due to Fibre Array Irregularities for Thermally and Transversely Loaded CF/Epoxy Composites
    Masaki Hojo, Masaaki Mizuno, Thomas Hobbiebrunken, Taiji Adachi, Mototsugu Tanaka, and Sung Kyu Ha
    2010-3, Plastic, Rubber and Composite, Vol. 39, No. 2, pp. 99-106. [Link]
  • Coupling between Axial Stretch and Bending/twisting Deformation of Actin Filaments Caused by a Mismatched Centroid from the Center Axis
    Hidetaka Yamaoka and Taiji Adachi
    2010-2, International Journal of Mechanical Science, Vol. 52, No. 2, pp. 329-333. [Link]
  • Mode I Fatigue Delamination of Zanchor-Reinforced CF/Epoxy Laminates
    Masaki Hojo, Kyosei Nakashima, Takayuki Kusaka, Mototsugu Tanaka, Taiji Adachi, Toshiyasu Fukuoka, and Masayasu Ishibashi
    2010-1, International Journal of Fatigue, Vol. 32, No. 1, pp. 37-45. [Link]

  • Dynamic Coupling between Actin Network Flow and Turnover Revealed by Flow Mapping in the Lamella of Crawling Fragments
    Kennedy O Okeyo, Taiji Adachi, Masaki Hojo
    2009-12, Biochemical and Biophysical Research Communications, Vol. 390, No. 3, pp. 797-802. [Link]
  • Osteocyte Calcium Signaling Response to Bone Matrix Deformation
    Taiji Adachi, Yuki Aonuma, Shin-ichi Ito, Mototsugu Tanaka, Masaki Hojo, Teruko-Takano Yamamoto, and Hiroshi Kamioka
    2009-11, Journal of Biomechanics, Vol. 42, No. 15, pp. 2507-2512. [Link]
  • Actomyosin Contractility Spatiotemporally Regulates Actin Network Dynamics in Migrating Cells
    Kennedy Omondi Okeyo, Taiji Adachi, Junko Sunaga, and Masaki Hojo
    2009-11, Journal of Biomechanics, Vol. 42, No. 15, pp. 2540-2548. [Link]
  • Asymmetric Intercellular Communication between Bone Cells: Propagation of the Calcium Signaling
    Taiji Adachi, Yuki Aonuma, Keisuke Taira, Masaki Hojo, Hiroshi Kamioka
    2009-11, Biochemical and Biophysical Research Communications, Vol. 389, No. 3, pp. 495-500. [Link]
  • Fluid Pressure Response in Poroelastic Materials Subjected to Cyclic Loading
    Yoshitaka Kameo, Taiji Adachi, and Masaki Hojo
    2009-11, Journal of the Mechanics and Physics of Solids, Vol. 57, No. 11, pp. 1815-1827. [Link]
  • Change in Fatigue Property and its Relation to Critical Current for YBCO Coated Conductor with Additional Cu Layer
    Yusuke Yoshida, Masaki Hojo, Michinaka Sugano, Taiji Adachi, Yasuhiro Inoue, Koji Shikimachi, Naoki Hirano, Shigeo Nagaya
    2009-10, Physica C, Vol. 469, No. 15-20, pp. 1476-1479. [Link]
  • Calcium Response in Single Osteocytes to Locally Applied Mechanical Stimulus: Differences in Cell Process and Cell Body
    Taiji Adachi, Yuki Aonuma, Mototsugu Tanaka, Masaki Hojo, Teruko Takano-Yamamoto, and Hiroshi Kamioka
    2009-8, Journal of Biomechanics, Vol. 42, No. 12, pp. 1989-1995. [Link]
  • Effect of Fiber Array Irregularities on Microscopic Interfacial Normal Stress States of Transversely Loaded UD-CFRP from Viewpoint of Failure Initiation
    Masaki Hojo, Masaaki Mizuno, Thomas Hobbiebrunken, Taiji Adachi, Mototsugu Tanaka, Sung Kyu Ha
    2009-6, Composites Science and Technology, Vol. 69, pp. 1726-1734. [Link]
  • Coarse-grained Modeling and Simulation of Actin Filament Behavior Based on the Brownian Dynamics Method
    Yoshitaka Shimada, Taiji Adachi, Yasuhiro Inoue, and Masaki Hojo
    2009-6, Molecular and Cellular Biomechanics, Vol. 6, No. 3, pp. 161-174. [Link]
  • Computer Simulation of Trabecular Remodeling in Human Proximal Femur Using Large-Scale Voxel FE Models: Approach to Understanding Wolff's Law
    Ken-ichi Tsubota, Yusuke Suzuki, Tomonori Yamada, Masaki Hojo, Akitake Makinouchi, and Taiji Adachi
    2009-5, Journal of Biomechanics, Vol. 42, No. 8, pp. 1088-1094. [Link]
  • Strain Field in Actin Filament Network in Lamellipodia of Migrating Cells: Implication for Network Reorganization
    Taiji Adachi, Kennedy Omondi Okeyo, Yoshimichi Shitagawa, and Masaki Hojo
    2009-2, Journal of Biomechanics, Vol. 42, No. 3, pp. 297-302. [Link]
  • In situ Observation of Interfacial Crack Propagationin GF/Epoxy Model Composite Using Bifiber Specimens in Mode I and Mode II Loading
    Masaki Hojo, Yukinobu Matsushita, Mototsugu Tanaka, and Taiji Adachi
    2008-10, Composite Science and Technology, Vol. 68, pp. 2678-2689. [Link]
  • Transient Response of Fluid Pressure in a Poroelastic Material under Uniaxial Cyclic Loading
    Yoshitaka Kameo, Taiji Adachi, and Masaki Hojo
    2008-4, Journal of the Mechanics and Physics of Solids, Vol. 56, No. 5, pp. 1794-1805. [Link]
  • Simultaneous Observation of Calcium Signaling Response and Membrane Deformation due to　Localized Mechanical Stimulus in Single Osteoblast-like Cells
    Taiji Adachi, Katsuya Sato, Norio Higashi, Yoshihiro Tomita, and Masaki Hojo,
    2008-1, Journal of the Mechanical Behavior of Biomedical Materials (JMBBM), Vol. 1, No. 1, pp 43-50. [Link]
  • Direct Measurement of Mechanical Properties of Bi2223 Filament Using Ag Alloy Removed Tape
    Masaki Hojo, Masahiro Hashimoto, Mototsugu Tanaka, Taiji Adachi, Michinaka Sugano, Shojiro Ochiai, and Kozo Osamura,
    2007-10, Physica C, Vol. 463-465, pp. 863-866. [Link]
  • Measurement of Local Strain on Cell Membrane at Initiation Point of Calcium Signaling Response to Applied Mechanical Stimulus in Osteoblastic Cell
    Katsuya Sato, Taiji Adachi, Daisuke Ueda, Masaki Hojo, and Yoshihiro Tomita
    2007-4, Journal of Biomechanics, Vol. 40, No. 6, pp. 1246-1255. [Link]
  • Two-Dimensional Quantitative Analysis of Preferential Alignment of BAp c-axis for Isolated Human Trabecular Bone Using Microbeam X-ray Diffractometer with a Transmission Optical System
    Sayaka Miyabe, Takayoshi Nakano, Takuya Ishimoto, Naoki Takano, Taiji Adachi, Hiroyoshi Iwaki, Akio Kobayashi, Kunio Takaoka, and Yukichi Umakoshi
    2007-3, Materials Transactions, Vol. 48, No. 3, pp. 343-347. [Link]
  • Effects of Spatial Distribution of Defects on Bending Deformation and Critical Current in Bi2223/Ag Superconducting Composite Tapes
    Masaki Hojo, M. Nakamura, Mototsugu Tanaka, Taiji Adachi, Michinaka Sugano, Shojiro Ochiai, and Kozo Osamura
    2007-1, Materials Science Forum, Vols. 539-543, pp. 919-924.
  • Evaluation of Interfacial Strength in CF/Epoxies using FEM and in-situ Experiments Thomas Hobbiebrunken, Masaki Hojo, Taiji Adachi, Claas De Jong and Bodo Fiedler
    2006-12, Composites Part A: Applied Science and Manufacturing, Vol. 37, No. 12, pp. 2248-2256. [Link]
  • Computer Simulation Study on Local and Integral Mechanical Quantities at Single Trabecular Level as Candidates of Remodeling Stimuli
    Ken-ichi Tsubota and Taiji Adachi
    2006-10, Journal of Biomechanical Science and Engineering, Vol. 1, No. 1, pp. 124-135. [Link]
  • Local Disassembly of Actin Stress Fibers Induced by Selected Release of Intracellular Tension in Osteoblastic Cell
    Katsuya Sato, Taiji Adachi, Yasuhito Shirai, Naoaki Saito, and Yoshihiro Tomita
    2006-10, Journal of Biomechanical Science and Engineering, Vol. 1, No. 1, pp. 204-214. [Link]
  • Mode I and II Interlaminar Fracture Toughness and Fatigue Delamination of CF/Epoxy Laminates with Self-Same Epoxy Interleaf
    Masaki Hojo, Tadashi Ando, Mototsugu Tanaka, Taiji Adachi, Shojiro Ochiai, and Yoshihiro Endo 2006-10, International Journal of Fatigue, No. 28, Vol. 10, pp. 1154-1165. [Link]
  • Framework for Optimal Design of Porous Scaffold Microstructure by Computational Simulation of Bone Regeneration
    Taiji Adachi, Yuki Osako, Mototsugu Tanaka, Masaki Hojo, and Scott J. Hollister
    2006-7, Biomaterials, Vol. 27, No. 21, pp. 3964-3972. [Link]
  • Analysis of Mesoscopic Stress States with Delamination and their Relation to Critical Current under Bending Deformation in Bi2223/Ag Superconducting Composite Tapes
    Masaki Hojo, Mitsuhiro Nakamura, Mototsugu Tanaka, Taiji Adachi, Michinaka Sugano, Shojiro Ochiai, and Kozo Osamura
    2005-11, Superconductor Science and Technology, Vol. 18, No. 12, pp. S356-363. [Link]
  • Influence of Delamination Location on Mesoscopic Stress State and Critical Current under Bending Deformation in Bi2223/Ag Superconducting Composite Tapes Masaki Hojo, M. Nakamura, Mototsugu Tanaka, Taiji Adachi, M. Sugano, S.Ochiai and K. Osamura
    2005-10, Physica C, Vols. 426-431, Part 2, pp. 1205-1210. [Link]
  • Quantitative Evaluation of Threshold Fiber Strain that Induces Reorganization of Cytoskeletal Actin Fiber Structure in Osteoblastic Cells
    Katsuya Sato, Taiji Adachi, Mamoru Matsuo, and Yoshihiro Tomita
    2005-9, Journal of Biomechanics, Vol. 38, No. 9, pp. 1895-1901. [Link]
  • Spatial and Temporal Regulation of Cancellous Bone Structure: Characterization of a Rate Equation of Trabecular Surface Remodeling
    Ken-ichi Tsubota and Taiji Adachi
    2005-5, Medical Engineering & Physics, Vol. 27, No. 4, pp. 305-311. [Link]
  • Investigation of Mechanical Behavior of Copper in Nb3Sn Superconducting Composite Wire
    Masaki Hojo, Tomoe Matsuoka, Mitsuhiro Nakamura, Mototsugu Tanaka, Taiji Adachi, Shojiro Ochiai, and Katsumi Miyashita
    2004-10, Physica C, Vol. 412-14, pp. 1261-1266. [Link]
  • Directional Dependence of Osteoblastic Calcium Response to Mechanical Stimuli
    Taiji Adachi, Katsuya Sato, and Yoshihiro Tomita
    2003-11, Biomechanics and Modeling in Mechanobiology, Vol. 2, No. 2, pp. 73-82. [Link]
  • Effects of a Fixation Screw on Trabecular Structural Changes in a Vertebral Body Predicted by Remodeling Simulation of Trabecular Surface Remodeling
    Ken-ichi Tsubota, Taiji Adachi, and Yoshihiro Tomita
    2003-6, Annals of Biomedical Engineering, Vol. 31, No. 6, pp. 733-740. [Link]
  • Functional Adaptation of Cancellous Bone in Human Proximal Femur Predicted by Trabecular Surface Remodeling Simulation toward Uniform Stress State
    Ken-ichi Tsubota, Taiji Adachi, and Yoshihiro Tomita
    2002-12, Journal of Biomechanics, Vol. 35, No. 12, pp. 1541-1551. [Link]
  • Trabecular Surface Remodeling Simulation for Cancellous Bone Using Microstructural Voxel Finite Element Models
    Taiji Adachi, Ken-ichi Tsubota, Yoshihiro Tomita and Scott J. Hollister
    2001-10, Journal of Biomechanical Engineering, Vol. 123, No. 5, pp. 403-409. [Link]
  • Computational Simulation of Deformation Behavior of 2D-Lattice Continuum
    Taiji Adachi, Yoshihiro Tomita, and Masao Tanaka
    1998-7, International Journal of Mechanical Science, Vol. 40, No. 9, pp. 857-866. [Link]
  • Uniform Stress State in Bone Structure with Residual Stress
    Taiji Adachi, Masao Tanaka, and Yoshihiro Tomita
    1998-6, Journal of Biomechanical Engineering, Vol. 120, No.3, pp. 342-347.[Link]
  • Simulation of Trabecular Surface Remodeling Based on Local Stress Nonuniformity
    Taiji Adachi, Yoshihiro Tomita, Hiroshi Sakaue, and Masao Tanaka
    1997-12, JSME International Journal, Vol. 40C, No. 4, pp. 782-792. [Link]
  • Modelling and Application of Constitutive Equation for Glassy Polymer Based on Nonaffine Network Theory
    Yoshihiro Tomita, Taiji Adachi, and Shigeyuki Tanaka
    1997-9, European Journal of Mechanics, A/Solids, Vol. 16, No. 5, pp. 745-755 [Link]
  • Computational Simulation of the Three-Dimensional Neck Propagation in Polymeric Specimens under Tension and Hybrid Identification of Constitutive Equation
    Yoshihiro Tomita, Taiji Adachi, and Sung Sik Park
    1997-4, International Journal of Mechanical Science, Vol. 39, No. 8, pp. 913-923. [Link]
  • Mechanical Remodeling of Bone Structure Considering Residual Stress
    Masao Tanaka, Taiji Adachi, and Yoshihiro Tomita
    1996-7, JSME International Journal, Vol. 39A, No. 3, pp. 297-305. [Link]
  • Preliminary Study on Mechanical Bone Remodeling Permitting Residual Stress
    Masao Tanaka and Taiji Adachi
    1994-1, JSME International Journal, Vol. 37A, No. 1, pp. 87-95. [Link]


安達泰治

京都大学 再生医科学研究所 教授
附属ナノ再生医工学研究センター
バイオメカニクス研究領域

〒606-8507 京都市左京区聖護院川原町53
再生医科学研究所 東館415室
adachifrontier.kyoto-u.ac.jp

研究分野

バイオメカニクス
計算力学

経歴

愛媛県立 松山東高等学校 卒業 (1986)
神戸大学 工学部 機械工学科 卒業 (1990)
大阪大学 大学院基礎工学研究科 物理系専攻 修士課程 修了 (1992)
神戸大学 工学部 機械工学科 (1992 助手，1998 助教授)
京都大学 大学院工学研究科 機械工学専攻 (2004 助教授)
京都大学 大学院工学研究科 機械理工学専攻 (2005 助教授, 2007 准教授)
京都大学 再生医科学研究所 附属ナノ再生医工学研究センター バイオメカニクス研究領域 (2010- 教授)

ミシガン大学 医学部 整形外科基礎研究室 特別研究員 (1997-1999)
日本学術振興会 海外特別研究員 (1998-1999)
神戸大学 大学院自然科学研究科 (1998-2004)
理化学研究所 客員研究員 (1999-)
理化学研究所 VCADシステム研究プログラム 細胞シミュレーションチーム チームリーダー (2006-2011）

受賞

平成２０年４月
　　 日本機械学会賞（論文）
　　 「骨再生シミュレーションを用いたポーラススカフォールドの設計手法の提案」
平成１９年１２月
　　 　APACM Award for Young Investigator in Computational Mechanics
　　 　(Asian Pacific Association for Computational Mechanics)
平成１８年１１月
　　　日本臨床バイオメカニクス学会　学会奨励賞
　　　　「海綿骨欠損内の骨梁構造形成に及ぼす力学的因子の影響」
平成１７年　７月
　　　JACM Award for Young Investigators in Computational Mechanics
　　　　(Japan Association for Computational Mechanics)
平成１５年　９月　
　　　日本エム・イー学会生体医工学シンポジウムベストリサーチアワード
　　　　「アクチン細胞骨格の組織化度が培養骨芽細胞の力学応答特性に及ぼす影響」
平成１５年　３月　
　　　神戸大学KTC機械クラブ賞
平成１４年　５月　
　　　日本設計工学会The Most Interesting Reading賞
　　　　「人工股関節設計の現状と課題」
平成１４年　４月　
　　　日本機械学会賞（論文）
　　　　「デジタルイメージモデルを用いた海綿骨の力学的再構築シミュレーション」
平成１３年１２月　
　　　日本機械学会材料力学部門講演会M＆M2001優秀講演賞
　　　　「表面応力の一様化を目指した人工股関節用ステムの形状決定シミュレーション」
平成１３年　５月　
　　　日本エム・イー学会科学新聞賞・研究奨励賞・阪本研究刊行助成賞・阿部賞　
　　　　「培養骨芽細胞内カルシウムとアクチンフィラメントの力学的刺激応答」
平成１２年　１月　
　　　日本機械学会バイオエンジニアリング部門瀬口賞　
　　　　「バイオエンジニアリングの分野における優れた研究」
平成１０年４月　
　　　日本機械学会 奨励賞（研究）　
　　　　「骨の力学的再構築と構造形成に関するバイオメカニクス的研究」
平成　７年１２月　
　　　NCP研究会瀬口フロンティア賞　
　　　　「骨梁表面再構築シミュレーション」

著書

生体細胞・組織のリモデリングのバイオメカニクス ME教科書シリーズ (B-6)
林 紘三郎, 安達 泰治, 宮崎 浩(amazon.co.jp)

主な研究プロジェクト

〇日本学術振興会　最先端・次世代研究開発支援プログラム（平成22〜25年度）
　テーマ：生体システムの構造・機能適応ダイナミクスの力学的理解（代表）

〇文部科学省　科学研究費補助金　特別推進研究（平成20〜24年度）
　プロジェクト：細胞の力覚機構の解明（代表：東北大学 佐藤正明）
　テーマ：単離骨細胞の力学刺激応答と細胞突起を介したネットワーク情報伝達の解析）
　　　

〇次世代生命体統合シミュレーションソフトウェアの研究開発（平成18年度〜）
　細胞スケール：アクチン細胞骨格の計算バイオメカニクス担当

〇理化学研究所　VCADシステム研究プログラム（平成18〜22年度）
　テーマ：細胞シミュレーション
　　　

〇財団法人先端医療振興財団
　知的クラスター創成事業神戸地域(平成17〜18年度）
　テーマ：三次元スキャホールドの製造システムの開発
　代表研究者：北條正樹（京都大学）

〇科学技術振興機構　重点地域研究開発推進事業（JSTイノベーションプラザ京都）
　（平成16〜19年度）
　プロジェクト：事業化のための育成研究
　テーマ：生分解性樹脂複合材料による骨再生用高機能スカフォールドの開発
　リンク：http://www.kyoto.jst-plaza.jp
　ニュース：http://www.kobe-np.co.jp/kobenews/keizai04/1001jc44410.html

〇日本学術振興会　21世紀COEプログラム（平成15〜19年度）
　タイトル：動的機能機械システムの数理モデルと設計論−複雑系の科学による機械工学の新たな展開−
　（拠点リーダー：土屋和雄，椹木哲夫）
　事業推進担当者（平成17〜19年度）

〇日本学術振興会　科学研究費補助金　特定領域研究（平成15〜18年度）
　プロジェクト：マイクロ・ナノバイオメカニクスの開拓
　テーマ：骨系細胞のナノ・ミクロ力学構造システムのバイオメカニクス
　リンク：http://www.wadalab.mech.tohoku.ac.jp/nano-biomech/

　　　

〇科学技術振興機構　戦略的創造研究推進事業（JST-CREST）（平成15〜18年度）
　研究領域：シミュレーション技術の革新と実用化基盤の構築
　プロジェクト：生体骨医療を目指したマルチプロフェッショナル・シミュレータ
　テーマ：海綿骨のミクロ・メゾ応力解析とその応用技術開発
　リンク：http://www.simulation.jst.go.jp/scholar/crest15/04takano.html
　DEMO MOVIE：『Level Set法を用いた骨梁リモデリングの三次元シミュレーション』
　　　　(wmv形式，42.9MB)

〇理化学研究所　生体力学シミュレーション研究プロジェクト
　（第１期：平成11〜15年度，第２期：平成16年度〜）
　プロジェクト：器官の損傷・治癒シミュレーション
　テーマ：骨の再生・リモデリングの生体力学シミュレーションと医工学への応用
　リンク：http://www.comp-bio.riken.jp/




〇兵庫県　新産業創造プログラム（平成15〜17年度）
　テーマ：生体吸収性を有する骨補填材の開発

所属学会

日本機械学会
日本生体医工学会
日本臨床バイオメカニクス学会
日本生物物理学会
日本バイオレオロジー学会
日本バイオマテリアル学会
日本骨代謝学会
日本骨形態計測学会
日本材料学会
European Society of Biomechanics
Biophysical Society
日本計算工学会
日本金属学会



(c) 2011-2014 Department of Biomechanics, Institute for Frontier Medical Sciences, Kyoto University