京都大学 ウイルス・再生医科学研究所 免疫制御分野
生田研究室 Ikuta Laboratory
Institute for Frontier Life and Medical Sciences

免疫系の分化・維持・応答の分子メカニズムをサイトカインの視点から研究しています。

原 崇裕（助教）Takahiro Hara

原 崇裕Takahiro Hara

研究内容

免疫細胞の発生・応答を支持するリンパ組織の微小環境について研究しています。特に、硬組織である骨髄は解析が困難なため、その微小構造・局所機能について詳細は明らかではありません。現在はIL-7産生性ストローマ細胞の種類や分布を指標として、骨髄微小環境の仕組みを調べています。

メッセージ

京都大学にて博士課程終了後、国立がん研究センター研究所において白血病の研究に従事した経験があります。今後も様々な骨髄関連疾患の治療法開発に繋がる研究をしていきたいと考えています。

教育経験

学内担当科目

  • 生命科学研究の第一線に立つⅠ（全学共通科目）2012/04～2014/03
  • 生命科学研究の第一線に立つⅡ（全学共通科目）2014/04～2016/03
  • ウイルスと生命科学の最前線（全学共通科目）2016/04～継続中

学外非常勤講師

  • 福井大学 医学部 免疫学講義 2016/04～継続中

専門分野

免疫学、血液学、実験動物学

Publication list

  1. Cui, G., Shimba, A., Ma, G., Takahara, K., Tani-ichi, S., Zhu, Y., Asahi, T., Abe, A., Miyachi, H., Kitano, S., Hara, T., Yasunaga, J., Suwanai, H., Yamada, H., Matsuoka, M., Ueki, K., Yoshikai, Y., and Ikuta, K. (2020). IL-7R-dependent phosphatidylinositol 3-kinase competes with STAT5 signal to modulate T cell development and homeostasis. J. Immunol., 204: 844-857.
  2. Zhu, Y., Cui, G., Miyauchi, E., Nakanishi, Y., Mukohira, H., Shimba, A., Abe, S., Tani-ichi, S., Hara, T., Nakase, H., Chiba, T., Sehara-Fujisawa, A., Seno, H., Ohno, H., and Ikuta, K. (2020). Intestinal epithelial cell-derived IL-15 determines local maintenance and maturation of intraepithelial lymphocytes in the intestine. Int. Immunol., 32: 307-319.
  3. Tani-ichi, S., Wagatsuma, K., Cui, G., Abe, A., Miyachi, H., Kitano, S., Hara, T., and Ikuta, K. (2020). Innate-like CD27+CD45RBhigh γδ T cells require TCR signaling for homeostasis in peripheral lymphoid organs. J. Immunol., 204: 2671-2684.
  4. Mukohira, H., Hara, T., Abe, S., Tani-ichi, S., Sehara-Fujisawa, A., Nagasawa, T., Tobe, K., and Ikuta, K. (2019). Mesenchymal stromal cells in bone marrow express adiponectin and are efficiently targeted by an adiponectin promoter-driven Cre transgene. Int. Immunol., 31: 729-741.
  5. Shimba A, Cui G, Tani-ichi S, Ogawa M, Abe S, Okazaki F, Kitano S, Miyachi H, Yamada H, Hara T, Yoshikai Y, Nagasawa T, Schütz G, and Ikuta K. Glucocorticoids drive diurnal oscillations in T cell distribution and responses by inducing interleukin-7 receptor and CXCR4. Immunity, 48: 286-298, 2018.
  6. Gomes AC*, Hara T*†, Lim VY*, Herndler-Brandstetter D, Nevius E, Sugiyama T, Tani-ichi S, Schlenner S, Richie E, Rodewald HR, Flavell RA, Nagasawa T, Ikuta K, Pereira JP†. Hematopoietic stem cell niches produce lineage-instructive signals to control multipotent progenitor differentiation. Immunity, 45: 1219-1231, 2016.
    *Co-first author, †Corresponding author
  7. Shinoda K, Hirahara K, Iinuma T, Ichikawa T, Suzuki AS, Sugaya K, Tumes DJ, Yamamoto H, Hara T, Tani-Ichi S, Ikuta K, Okamoto Y, Nakayama T. Thy1+IL-7+ lymphatic endothelial cells in iBALT provide a survival niche for memory T-helper cells in allergic airway inflammation. Proc Natl Acad Sci USA. 113: E2842-2851, 2016.
  8. Abe A, Tani-ichi S, Shitara S, Cui G, Yamada H, Miyachi H, Kitano S, Hara T, Abe R, Yoshikai Y, and Ikuta K. An enhancer of the IL-7 receptor α-chain locus controls IL-7 receptor expression and maintenance of peripheral T cells. J Immunol, 195: 3129-3138, 2015.
  9. Wagatsuma K*, Tani-ichi S*, Liang B, Shitara S, Ishihara K, Abe M, Miyachi H, Kitano S, Hara T, Nanno M, Ishikawa H, Sakimura K, Nakano M, Kimura H, and Ikuta K. STAT5 orchestrates local epigenetic changes for chromatin accessibility and rearrangements by direct binding to the TCRγ locus. J Immunol, 195: 1804-1814, 2015.
    *equal contribution.
  10. Tsuneto M, Kajikhina E, Seiler K, Reimer A, Tornack J, Bouquet C, Simmons S, Knoll M, Wolf I, Tokoyoda K, Hauser A, Hara T, Tani-ichi S, Ikuta K, Grun JR, Grutzkau A, Engels N, Wienands J, Yanagisawa Y, Ohnishi K, and Melchers F. Environments of B cell development. Immunol Lett, 157:60-63, 2014.
  11. Cui G, Hara T, Simmons S, Wagatsuma K, Abe A, Miyachi H, Kitano S, Ishii M, Tani-ichi S, and Ikuta K. Characterization of the interleukin-15 niche in primary and secondary lymphoid organs in vivo. Proc Natl Acad Sci USA, 111:1915-1920, 2014.
  12. Tsuneto M, Tokoyoda K, Kajikhina E, Hauser AE, Hara T, Tani-ichi S, Ikuta K, and Melchers F. B cell progenitors and precursors change their microenvironment in fetal liver during early development. Stem Cells, 31:2800-2812, 2013.
  13. Hanazawa A, Hayashizaki K, Shinoda K, Yagita H, Okumura K, Lohning M, Hara T, Tani-ichi S, Ikuta K, Eckes B, Radbruch A, Tokoyoda K, and Nakayama T. CD49b-dependent establishment of T helper cell memory. Immunol Cell Biol, 91:524-531, 2013.
  14. Shitara S*, Hara T*, Liang B, Wagatsuma K, Zuklys S, Hollander GA, Nakase H, Chiba T, Tani-ichi S, and Ikuta K. Interleukin-7 produced by thymic epithelial cells plays a major role in the development of thymocytes and TCRγδ+ intraepithelial lymphocytes. J Immunol, 190:6173-6179, 2013.
    *equal contribution.
  15. Tani-ichi S, Shimba A, Wagatsuma K, Miyachi H, Kitano S, Imai K, Hara T, and Ikuta K. The interleukin-7 receptor controls development and maturation of late stages of thymocyte subpopulations. Proc Natl Acad Sci USA, 110:612-617, 2013.
  16. Liang B, Hara T, Wagatsuma K, Zhang J, Maki K, Miyachi H, Kitano S, Yabe-Nishimura C, Tani-ichi S, and Ikuta K. Role of hepatocyte-derived IL-7 in maintenance of intrahepatic NK T and T cells and development of B cells in fetal liver. J Immunol, 189:4444-4450, 2012.
  17. Hara T, Shitara S, Imai K, Miyachi H, Kitano S, Yao H, Tani-ichi S, and Ikuta K. Identification of interleukin-7-producing cells in primary and secondary lymphoid organs using IL-7-GFP knock-in mice. J Immunol, 189:1577-1584, 2012.
  18. Hara T, Katakai T, Lee J-H, Nambu Y, Nakajima-Nagata N, Gonda H, Sugai M, Shimizu A. A transmembrane chemokine, CXC chemokine ligand 16, expressed by lymph node fibroblastic reticular cells has the potential to regulate T cell migration and adhesion. Int Immunol, 18:301-311, 2006.
  19. Katakai T, Hara T, Sugai M, Gonda H, Shimizu A, Node L, Fibroblastic reticular cells construct the stromal reticulum via contact with lymphocytes. J Exp Med, 200:783-795, 2004.
  20. Lee J-H, Katakai T, Hara T, Gonda H, Sugai M, Shimizu A. Roles of p-ERM and Rho-ROCK signaling in lymphocyte polarity and uropod formation. J Cell Biol, 167:327-337, 2004.
  21. Katakai T, Hara T, Lee J-H, Gonda H, Sugai M, Shimizu A. A novel reticular stromal structure in lymph node cortex: an immuno-platform for interactions among dendritic cells, T cells, and B cells. Int Immunol, 16:1133-1142, 2004.
  22. Katakai T, Hara T, Sugai M, Gonda H, Shimizu A. Th1-biased tertiary lymphoid tissue supported by CXC chemokine ligand 13-producing stromal network in chronic lesions of autoimmune gastritis. J Immunol, 171:4359-4368, 2003.
  23. Katakai T, Hara T, Sugai M, Gonda H, Nambu Y, Matsuda E, Agata Y, Shimizu A. Chemokine-independent preference for T-helper-1 cells in transendothelial migration. J Biol Chem, 277:50948-50958, 2002.