京都大学 ウイルス・再生医科学研究所 免疫制御分野
生田研究室 Ikuta Laboratory
Institute for Frontier Life and Medical Sciences

免疫系の分化・維持・応答の分子メカニズムをサイトカインの視点から研究しています。

1999年以前の論文Publication (-1999)

1999年以前の論文

  1. Nosaka, T., Kawashima, T., Misawa, K., Ikuta, K., Mui, A. L. F. and Kitamura, T. (1999) STAT5 as a molecular regulator of proliferation, differentiation, and apoptosis in hematopoietic cells. EMBO J. 18:4754-4765.
  2. Ye, S.-K., Maki, K., Kitamura, T., Sunaga, S., Akashi, K., Domen, J., Weissman, I. L., Honjo, T., and Ikuta, K. (1999). Induction of germline transcription in the TCRγ locus by Stat5: implications for accessibility control by the IL-7 receptor. Immunity, 11:213-223.
  3. Watanabe, N., Nisitani, S., Ikuta, K., Suzuki, M., Chiba, T., and Honjo, T. (1999). Expression levels of B cell surface immunoglobulin regulate efficiency of allelic exclusion and size of autoreactive B-1 cell compartment. J. Exp. Med., 190:461-469.
  4. Sakiyama, T., Ikuta, K., Nisitani, S., Takatsu, K. and Honjo, T. (1999). Requirement of IL-5 for induction of autoimmune hemolytic anemia in anti-red blood cell autoantibody transgenic mice. Int. Immunol., 11:995-1000.
  5. Yoshida, H., Honda, K., Shinkura, R., Adachi, S., Nishikawa, S., Maki, K., Ikuta, K., and Nishikawa, S.-I. (1999). IL-7 receptor α+ CD3- cells in the embryonic intestine induces the organizing center of Peyer's patches. Int. Immunol., 11:643-655.
  6. Shinkura, R., Kitada, K., Matsuda, F., Tashiro, K., Ikuta, K., Suzuki, M., Kogishi, K., Serikawa, T., and Honjo, T. (1999). Alymphoplasia (aly) is caused by a point mutation in the mouse NF-κB inducing kinase gene. Nat. Genet., 22:74-77.
  7. Kodaira, Y., Ikuta, K., Tanaka, S., and Yokomuro, Y. (1999). Antigen-driven clonal accumulation of peritoneal γδ T cells in vivo. Immunol. Invest., 28:137-148.
  8. Ishii, S., Kuwaki, T., Nagase, T., Maki, K., Tashiro, F., Sunaga, S., Cao, W-H., Kume, K., Fukuchi, Y., Ikuta, K., Miyazaki, J., Kumada, M., and Shimizu, T. (1998). Impaired anaphylactic responses with intact sensitivity to endotoxin in mice lacking a platelet-activating factor receptor. J. Exp. Med., 187:1779-1788.
  9. Adachi, S., Yoshida, H., Honda, K., Maki, K., Saijo, K., Ikuta, K., Saito, T., and Nishikawa, S. (1998). Essential role of IL-7 receptor α in the formation of Peyer's patch anlage. Int. Immunol. 10:1-6.
  10. Uozumi, N., Kume, K., Nagase, T., Nakatani, N., Ishii, S., Tashiro, F., Komagata, Y., Maki, K., Ikuta, K., Ouchi, Y., Miyazaki, J., and Shimizu, T. (1997). Role of cytosolic phospholipase A2 in allergic response and parturition. Nature, 390:618-622.
  11. Miyaura C., Onoe, Y., Inada, M., Maki, K., Ikuta, K., Ito, M., and Suda, T. (1997). Increased B-lymphopoiesis by interleukin 7 induces bone loss in mice with intact ovarian function: Similarity to estrogen deficiency. Proc. Natl. Acad. Sci. USA., 94:9360-9365.
  12. Takeuchi, T., Ueki, T., Sunaga, S., Ikuta, K., Sasaki, Y., Li, B., Moriyama, N., Miyazaki, J., and Kawabe, K. (1997). Murine interleukin 4 transgenic heart allograft survival prolonged with down-regulation of the Th1 cytokine mRNA in grafts. Transplantation., 64:152-157.
  13. Sunaga, S., Maki, K., Komagata, Y., Miyazaki, J., and Ikuta, K. (1997). Developmentally ordered V-J recombination in mouse T cell receptor γ locus is not perturbed by targeted deletion of the Vγ4 gene. J. Immunol., 158:4223-4228.
  14. Ishii, S., Nagase, T., Tashiro, F., Ikuta, K., Sato, S., Waga, I., Kume, K., Miyazaki, J., and Shimizu, T. (1997). Bronchial hyperreactivity, increased endotoxin lethality and melanocytic tumorigenesis in transgenic mice overexpressing platelet-activating factor receptor. EMBO J., 16:133-142.
  15. Sunaga, S., Maki, K., Lagasse, E., Blanco, J. C. G., Ozato, K., Miyazaki, J., and Ikuta, K. (1997). Myeloid differentiation is impaired in transgenic mice with targeted expression of a dominant negative form of retinoid X receptor β. Brit. J. Haematol., 96:19-30.
  16. Sunaga, S., Maki, K., Komagata, Y., Ikuta, K., and Miyazaki, J. (1997). Efficient removal of loxP-flanked sequences in a gene-targeted locus by transient expression of Cre recombinase in fertilized eggs. Mol. Reprod. Dev., 46: 109-113.
  17. Maki, K., Sunaga, S., and Ikuta, K. (1996). The V-J recombination of T cell receptor-γ genes is blocked in interleukin-7 receptor-deficient mice. J. Exp. Med., 184:2423-2427.
  18. Kanamori, Y., Ishimaru, K., Nanno, M., Maki, K., Ikuta, K., Nariuchi, H., and Ishikawa, H. (1996). Identification of novel lymphoid tissues in murine intestinal mucosa where clusters of c-kit+ IL-7R+ Thy1+ lympho-hemopoietic progenitors develop. J. Exp. Med., 184:1449-1459.
  19. Aoe, T., Okamoto, Y., Arase, H., Ikuta, K., Miyazaki, J., Ono, S., Otuji, M., Ohno, H., Miyatake, S., and Saito, T. (1996). Preferential requirement of CD3ζ-mediated signals for development of immature rather than mature thymocytes. Int. Immunol., 8:1055-1066.
  20. Yoshida, T., Ikuta, K., Sugaya, H., Maki, K., Takagi, M., Kanazawa, H., Sunaga, S., Kinashi, T., Yoshimura, K., Miyazaki, J., Takaki, S., and Takatsu, K. (1996) Defective B-1 cell development and impaired immunity against Angiostrongylus cantonensis in IL-5Rα-deficient mice. Immunity, 4:483-494.
  21. Maki, K., Sunaga, S., Komagata, Y., Kodaira, Y., Mabuchi, A., Karasuyama, H., Yokomuro, K., Miyazaki, J., and Ikuta, K. (1996) Interleukin 7 receptor-deficient mice lack γδ T cells. Proc. Natl. Acad. Sci. USA., 93:7172-7177.
  22. Komagata, Y., Weissman, I. L., and Ikuta, K. (1996) Heterogeneity of N insertion capacity in fetal hematopoietic stem cells. Int. Immunol., 8:837-845.
  23. Komagata, Y., Masuko, K., Tashiro, F., Kato, T., Ikuta, K., Nishioka, K., Ito, K., Miyazaki, J., and Yamamoto, K. (1996) Clonal prevalence of T cells infiltrating into the pancreas of prediabetic non-obese diabetic mice. Int. Immunol., 8:807-814.
  24. Kodaira, Y., Yokomuro, K., Tanaka, S., Miyazaki, J., and Ikuta, K. (1996) Developmental heterogeneity of Vγ1.1 T cells in the mouse liver. Immunol., 87:213-219.
  25. Ishihara, H., Tashiro, F., Ikuta, K., Asano, T., Katagiri, H., Inukai, K., Kikuchi, M., Yazaki, Y., Oka, Y., and Miyazaki, J. (1995) Inhibition of pancreatic β-cell glucokinase by antisense RNA expression in transgenic mice: mouse strain-dependent alteration of glucose tolerance. FEBS Letters, 371:329-332.
  26. Ikuta, K., and Komagata, Y. (1995). Developmental potential of fetal hematopoietic stem cells. In " Hematopoietic stem cells: Biology and therapeutic applications". Levitt, D. J., and Mertelsmann, R. eds. pp69-83.
  27. Fleming, W. H., Uchida, N., Ikuta, K., Spangrude, G. J., and Weissman, I. L. (1993). Functional heterogeneity is associated with the cell cycle status of murine hematopoietic stem cells. J. Cell Biol., 122:897-902.
  28. Ikuta, K., and Weissman, I. L. (1993). T lymphocyte development from fetal hematopoietic stem cells. Seminars in Dev. Biol., 4:371-378.
  29. Fleming, W. H., Alpern, E. J., Uchida, N., Ikuta, K., Zsebo, K. M., and Weissman, I. L. (1993). Steel factor influences the distribution and activity of murine hematopoietic stem cells in vivo. Proc. Natl. Acad. Sci. USA., 90:3760-3764.
  30. Ikuta, K., and Weissman, I. L. (1992). Evidence that hematopoietic stem cells express c-kit, but do not depend on steel factor for their generation. Proc. Natl. Acad. Sci. USA., 89:1502-1506.
  31. Ikuta, K., Uchida, N., Friedman, J., and Weissman, I. L. (1992). Lymphocyte development from stem cells. Annu. Rev. Immunol. 10:759-783.
  32. Ikuta, K., Kina, T., MacNeil, I., Uchida, N., Peault, B., Chien, Y., and Weissman, I. L. (1992). Development of γδ T cell subsets from fetal hematopoietic stem cells. Ann. N. Y. Acad. Sci. 651:21-32.
  33. Ikuta, K., and Weissman, I. L. (1991). The junctional modifications of a T cell receptor γ chain are determined at the level of thymic precursors. J. Exp. Med. 174:1279-1282.
  34. Ikuta, K., Ingolia, D. E., Friedman, J, Heimfeld, S., and Weissman, I. L. (1991). Mouse hematopoietic stem cells and the interaction of c-kit receptor and steel factor. Int. J. Cell Cloning 9:451-460.
  35. Spangrude, G., Heimfeld, S., Smith, L. G., Ikuta, K., and Weissman, I. L. (1990). Mouse hematopoietic stem cells. Blood 78:1395-1402.
  36. Ikuta, K., Kina, T., MacNeil, I., Uchida, N., Peault, B., Chien, Y., and Weissman, I. L. (1990). A developmental switch in thymic lymphocyte maturation potential occurs at the level of hematopoietic stem cells. Cell 62: 863-874.
  37. Ogawa, M., Ikuta, K., Katsura, Y., and Nishikawa, S. (1989). Stepwise progression of B cell malignancy occurred in a bone marrow stromal cell-dependent pre-B cell clone. Leukemia 3:282-288.
  38. Ogawa, M., Nishikawa, S., Ikuta, K., Yamamura, F., Naito, M., Takahashi, K., and Nishikawa, S. (1988). B cell ontogeny in murine embryo studied by a culture system with the monolayer of a stroma cell clone, ST2: B cell progenitor develops first in the embryonal body rather than in the yolk sac. EMBO J. 7:1337-1343.
  39. Maeda, M., Arima, N., Daitoku, Y., Kashihara, M., Okamoto, H., Uchiyama, T., Shirono, K., Matsuoka, M., Hattori, T., Takatsuki, K., Ikuta, K., Shimizu, A., Honjo, T., and Yodoi, J. (1987). Evidence for the interleukin-2 dependent expansion of leukemic cells in adult T cell leukemia. Blood 70:1407-1411.
  40. Ikuta, K., Takami, M., Kim, C. W., Honjo, T., Miyoshi, T., Tagaya, Y., Kawabe, T., and Yodoi, J. (1987). Human lymphocyte Fc receptor for IgE: Sequence homology of its cloned cDNA with animal lectins. Proc. Natl. Acad. Sci. USA. 84:819-823.
  41. Ikuta, K., Hattori, M., Wake, K., Kano, S., Honjo, T., Yodoi, J., and Minato, N. (1986). Expression and rearrangement of the α, β, γ chain genes of the T cell receptor in cloned murine large granular lymphocyte lines: no correlation with the cytotoxic spectrum. J. Exp. Med. 164:428-442.
  42. Ikuta, K., Ogura, T., Shimizu, A., and Honjo, T. (1986). A joining-diversity-joining complex generated by inversion mechanism and a variable-diversity complex in the β-chain gene of the human T-cell receptor. Nucl. Acids Res. 14:4899-4909.
  43. Ikuta, K., Ogura, T., Shimizu, A., and Honjo, T. (1985). Low frequency of somatic mutation in β-chain variable region genes of human T-cell receptors. Proc. Natl. Acad. Sci. USA. 82:7701-7705.
  44. Maeda, M., Shimizu, A., Ikuta, K., Okamoto, H., Kashihara, M., Uchiyama, T., Honjo, T., and Yodoi, J. (1985). Origin of human T-lymphotrophic virus I-positive T cell lines in adult T cell leukemia. Analysis of T cell receptor gene rearrangement. J. Exp. Med. 162:2169-2174.
  45. Yodoi, J., Okada, M., Tagaya, Y., Teshigawara, K., Fukui, K., Ishida, N., Ikuta, K., Maeda, M., Honjo, T., Osawa, H., Diamanstein, T., Tateno, M., and Yoshiki, T. (1985). Rat lymphoid cell lines producing human T cell leukemia virus. II Constitutive expression of rat interleukin 2 receptor. J. Exp. Med. 161:924-934.