京都大学 ウイルス・再生医科学研究所 免疫制御分野
生田研究室 Ikuta Laboratory
Institute for Frontier Life and Medical Sciences

免疫系の分化・維持・応答の分子メカニズムをサイトカインの視点から研究しています。

最近の業績Publication

  1. 2020
  2. 2019
  3. 2018
  4. 2017
  5. 2016
  6. 2015
  7. 2014
  8. 2013
  9. 2012
  10. 2011
  11. 2010
  12. 2009
  13. 2008
  14. 2007
  15. 2006
  16. 2005
  17. 2004
  18. 2003
  19. 2002
  20. 2001
  21. 2000

2020

  • Cui, G., Shimba, A., Ma, G., Takahara, K., Tani-ichi, S., Zhu, Y., Asahi, T., Abe, A., Miyachi, H., Kitano, S., Hara, T., Yasunaga, J., Suwanai, H., Yamada, H., Matsuoka, M., Ueki, K., Yoshikai, Y., and Ikuta, K. (2020). IL-7R-dependent phosphatidylinositol 3-kinase competes with STAT5 signal to modulate T cell development and homeostasis. J. Immunol., 204: 844-857.

    IL-7受容体下流シグナル因子であるSTAT5とPI3キナーゼがどのように役割分担し、機能を果たすのかを明らかにするため、新たに2種類のIL-7受容体に点変異を持つマウスモデルを構築した。STAT5とPI3キナーゼの間に競合的なシグナル伝達が起きていることを発見し、この競合性がT細胞の分化と維持を適切に制御していることを明らかにした。京都大学生命科学研究科・高原和彦准教授、九州大学生体防御医学研究所・吉開泰信教授との共同研究である。

  • Zhu, Y., Cui, G., Miyauchi, E., Nakanishi, Y., Mukohira, H., Shimba, A., Abe, S., Tani-ichi, S., Hara, T., Nakase, H., Chiba, T., Sehara-Fujisawa, A., Seno, H., Ohno, H., and Ikuta, K. (2020). Intestinal epithelial cell-derived IL-15 determines local maintenance and maturation of intraepithelial lymphocytes in the intestine. Int. Immunol., 32: 307-319.
  • Inokawa, H., Umemura, Y., Shimba, A., Kawakami, E., Koike, N., Tsuchiya, Y., Ohashi, M., Minami, Y., Cui, G., Asahi, T., Ono, R., Sasawaki, Y., Konishi, E., Yoo, S., Chen, Z., Teramukai, S., Ikuta, K., and Yagita, K. (2020). Chronic circadian misalignment accelerates immune senescence and abbreviates lifespan in mice. Sci. Rep., 10: 2569.
  • Tani-ichi, S., Wagatsuma, K., Cui, G., Abe, A., Miyachi, H., Kitano, S., Hara, T., and Ikuta, K. (2020). Innate-like CD27+CD45RBhigh γδ T cells require TCR signaling for homeostasis in peripheral lymphoid organs. J. Immunol., 204: 2671-2684.

    αβT細胞のホメオスタシスにはIL-7とTCRシグナルが必須である。一方、γδT細胞のホメオスタシスにはIL-15とIL-7が必要であることは知られていたが、TCRシグナルが必要かどうかは不明であった。TCRγ遺伝子のエンハンサー欠損マウスを作製し、γδTCRの発現を低下させることにより、IFN-γ産生型の一部のγδT細胞サブセットは末梢リンパ組織でのホメオスタシスにTCRシグナルを要求することを明らかにした。

2019

  • Rodríguez-Caparrós, A., García, V., Casal, Á, López-Ros, J., García-Mariscal, A., Tani-ichi, S., Ikuta, K., and Hernández-Munain, C. (2019). Notch signaling controls transcription via the recruitment of RUNX1 and MYB to enhancers during T cell development. J. Immunol., 202: 2460-2472.
  • Mukohira, H., Hara, T., Abe, S., Tani-ichi, S., Sehara-Fujisawa, A., Nagasawa, T., Tobe, K., and Ikuta, K. (2019). Mesenchymal stromal cells in bone marrow express adiponectin and are efficiently targeted by an adiponectin promoter-driven Cre transgene. Int. Immunol., 31: 729-741.

2018

  • Baumann, N., Torti, N., Welten, S. P. M., Barnstorf, I., Borsa, M., Pallmer, K., Oduro, J. D., Cicin-Sain, L., Ikuta, K., Ludewig, B., and Oxenius, A. (2018). Tissue maintenance of CMV-specific inflationary memory T cells by IL-15. PLos Pathogen, 14(4): e1006993.
  • Shimba, A., Cui, G., Tani-ichi, S., Ogawa, M., Abe, S., Okazaki, F., Kitano, S., Miyachi, H., Yamada, H., Hara, T., Yoshikai, Y., Nagasawa, T., Schütz, G., and Ikuta, K. (2018). Glucocorticoids drive diurnal oscillations in T cell distribution and responses by inducing interleukin-7 receptor and CXCR4. Immunity, 48: 286-298.

    強い免疫抑制作用を持つグルココルチコイドが、IL-7受容体とケモカイン受容体CXCR4の発現を誘導することで、T細胞の体内分布を制御し、T細胞の免疫応答能を高めることを明らかにした。生体内のグルココルチコイドがT細胞の免疫機能を高める働きをもつこと、内分泌系が免疫系を直接制御すること、免疫機能が日内変動することが示された。大阪大学長澤丘司教授、九州大学吉開泰信教授、ドイツがん研究センターGünther Schütz教授らとの共同研究である。

2017

  • Nakamizo, S., Honda, T., Adachi, A., Nagatake, T., Kunisawa, J., Kitoh, A., Otsuka, A., Dainichi, T., Nomura, T., Ginhoux, F., Ikuta, K., Egawa, G., and Kabashima, K. (2017).High fat diet exacerbates murine psoriatic dermatitis by increasing the number of IL-17-producing γδ T cells. Sci. Rep., 7: 14076.

2016

  • Gomes, A. C.*, Hara, T.*†, Lim, V. Y.*, Herndler-Brandstetter, D., Nevius, E., Sugiyama, T., Tani-ichi, S., Schlenner, S., Richie, E., Rodewald, H., Flavell, R. A., Nagasawa, T., Ikuta, K., and Pereira, J. P.† (2016). Hematopoietic stem cell niches produce lineage-instructive signals to control multipotent progenitor differentiation. Immunity, 45: 1219-1231. *Co-first author. †corresponding author.

    IL-7-GFPノックインマウスの骨髄を解析し、造血幹細胞を支持する間葉系前駆細胞や内皮細胞が、IL-7産生性およびIL-7非産生の亜集団に細分化されることを示した。IL-7産生性の亜集団はCXCL12やSCFも発現することで、多能性造血前駆細胞からリンパ球までの分化を方向付けるニッチとして働くことを明らかにした。Yale大学Pereira助教、大阪大学長澤丘司教授らとの共同研究である。

  • Gil-Cruz, C., Perez-Shibayama, C., Onder, L., Chai, Q., Cupovic, J., Cheng, H., Novkovic, M., Lang, P. A., Geuking, M. B., McCoy, K. D., Abe, S., Cui, G., Ikuta, K., Scandella, E., and Ludewig, B. (2016). Fibroblastic reticular cells regulate intestinal inflammation through IL-15-mediated control of group 1 ILCs. Nat. Immunol., 17: 1388-1396.
  • Shinoda, K., Hirahara, K., Iinuma, T., Ichikawa, T., Suzuki, A. S., Sugaya, K., Tumes, D. J., Yamamoto, H., Hara, T., Tani-ichi, S., Ikuta, K., Okamoto, Y., and Nakayama, T. (2016). Thy-1+IL-7+ lymphatic endothelial cells in iBALT provide a survival niche for memory T-helper cells in allergic airway inflammation. Proc. Natl. Acad. Sci. USA., 113 (20): E2842-2851.
  • Terashima, A., Okamoto, K., Nakashima, T., Akira, S., Ikuta, K. and Takayanagi, H. (2016). Sepsis-induced osteoblast ablation causes immunodeficiency. Immunity, 44: 1434-1443.
  • Huang, Y., Getahun, A., Heiser, R. A., Detanico, T. O., Kirchenbaum, G. A., Casper, T. L., Huang, C., Aydintug, M. K., Carding, S. R., Ikuta, K., Huang, H., Wysocki, L. J., Cambier, J. C., O'Brien, R. L., and Born, W. K. (2016). γδ T cells shape pre-immune peripheral B cell populations. J. Immunol., 196: 217-231.

2015

  • Nishijima, H., Kitano, S., Miyachi, H., Morimoto, J., Kawano, H., Hirota, F., Morita, R., Mouri, Y., Masuda, K., Imoto, I., Ikuta, K., and Matsumoto, M. (2015). Ectopic Aire expression in the thymic cortex reveals inherent properties of Aire as a tolerogenic factor within the medulla. J. Immunol., 195: 4641-4649.
  • Adachi, T., Kobayashi, T., Sugihara, E., Yamada, T., Ikuta, K., Pittaluga, S., Saya, H., Amagai, M., and Nagao, K. (2015). Hair follicle-derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma. Nat. Med., 21: 1272-1279.
  • Abe, A., Tani-ichi, S., Shitara, S., Cui, G., Yamada, H., Miyachi, H., Kitano, S., Hara, T., Abe, R., Yoshikai, Y., and Ikuta, K. (2015). An enhancer of the IL-7 receptor α-chain locus controls IL-7 receptor expression and maintenance of peripheral T cells. J. Immunol., 195: 3129-3138.

    IL-7レセプター遺伝子座の種を越えて保存されている領域CNS-1の欠失マウスを作製し、末梢T細胞においてIL-7レセプターの発現が低下することを示した。CNS-1欠失T細胞は体内における生存が低下しており、グルココルチコイドやTNF-αによるIL-7レセプターの誘導も失われていた。CNS-1領域がエンハンサーとして機能することが明らかとなった。東京理科大学生命医科学研究所・安部良教授、九州大学生体防御医学研究所・吉開泰信教授、山田久方准教授との共同研究である。

  • Wagatsuma, K.*, Tani-ichi, S.*, Liang, B., Shitara, S., Ishihara, K., Abe, M., Miyachi, H., Kitano, S., Hara, T., Nanno, M., Ishikawa, H., Sakimura, K., Nakano, M., Kimura, H., and Ikuta, K. (2015). STAT5 orchestrates local epigenetic changes for chromatin accessibility and rearrangements by direct binding to the TCRγ locus. J. Immunol., 195: 1804-1814. *equal contribution.

    TCRγ遺伝子座のJγ1プロモーターを含む940bpのDNA領域を欠失したマウスとJγ1プロモーターの3つのSTATモチーフに点突然変異を導入したマウスを作製し、STAT5がJγプロモーターに結合することが局所的なクロマチンのアクセシビリティとJγ1/ Eγクロマチンループ形成を誘導することで、TCRγ遺伝子座の組換えを引き起こすことを明らかにした。ヤクルト中央研究所・南野昌信博士、石川博通博士、新潟大学脳研究所・崎村建司教授、熊本大学・中尾光善教授、東京工業大学生命理工学研究科・木村宏教授との共同研究である。

  • Alp, Ö. S., Durlanik, S., Schulz, D., McGrath, M., Grün, J. R., Bardua, M., Ikuta, K., Sgouroudis, E., Riedel, R., Zehentmeier, S., Hauser, A. E., Tsuneto, M., Melchers, F., Tokoyoda, K., Chang, H-D., Thiel, A., and Radbruch, A. (2015). Memory CD8+ T cells colocalize with IL-7+ stromal cells in bone marrow and rest in terms of proliferation and transcription. Eur. J. Immunol., 45: 975-987.
  • Huang, Y., Heiser, R. A., Detanico, T. O., Getahun, A., Kirchenbaum, G. A., Aydintug, M. K., Smith, C. W., Carding, S. R., Ikuta, K., Huang, H., Wysocki, L. J., Cambier, J. C., O'Brien, R. L., and Born, W. K. (2015). γδ T cells affect IL-4 production and B cell tolerance. Proc. Natl. Acad. Sci. USA., 112(1):E39-48.
  • Nakamura, M., Shibata, K., Hatano, S., Sato, T., Ohkawa, Y., Yamada, H., Ikuta, K., and Yoshikai, Y. (2015). A genome-wide analysis identifies a Notch-RBP-Jκ-IL-7Rα axis that controls IL-17-producing γδ T cell homeostasis in mice. J. Immunol., 194: 243-251.

2014

  • Tsuneto, M., Kajikhina, E., Seiler, K., Reimer, A., Tornack, J., Bouquet, C., Simmons, S., Knoll, M., Wolf, I., Tokoyoda, K., Hauser, A., Hara, T., Tani-ichi, S., Ikuta, K., Grun, J. R., Grutzkau, A., Engels, N., Wienands, J., Yanagisawa, Y., Ohnishi, K., and Melchers, F. (2014). Environments of B cell development. Immunol. Lett., 157:60-63, 2014.
  • Cui, G., Hara, T., Simmons, S., Wagatsuma, K., Abe, A., Miyachi, H., Kitano, S., Ishii, M., Tani-ichi, S., and Ikuta, K. (2014). Characterization of the interleukin-15 niche in primary and secondary lymphoid organs in vivo. Proc. Natl. Acad. Sci. USA., 111:1915-1920.

    IL-15-CFPノックインマウスを作製し、IL-15産生細胞を蛍光タンパク質CFPで可視化した。骨髄の間葉系ストローマ細胞、胸腺髄質の上皮細胞、血管内皮細胞、リンパ節の線維芽細胞様細網細胞などでIL-15が産生されており、IL-15とIL-7の産生細胞は大きく異なることを示した。大阪大学医学研究科・石井優教授、Szandor Simmons博士との共同研究である。

2013

  • Tani-ichi, S., Shimba, A., Wagatsuma, K., Miyachi, H., Kitano, S., Imai, K., Hara, T., and Ikuta, K. (2013). The interleukin-7 receptor controls development and maturation of late stages of thymocyte subpopulations. Proc. Natl. Acad. Sci. USA., 110:612-617.
  • Sekai, M., Tani-ichi, S., Yoneyama, M., Fujita, T., Kina, T., and Ikuta, K. (2013). Lymphocyte-stromal cell interaction induces IL-7 expression by interferon regulatory factors. Mol. Immunol., 54:378-385.
  • Shitara, S., Hara, T., Liang, B., Wagatsuma, K., Zuklys, S., Hollander, G. A., Nakase, H., Chiba, T., Tani-ichi, S., and Ikuta, K. (2013). Interleukin-7 produced by thymic epithelial cells plays a major role in the development of thymocytes and TCRγδ+ intraepithelial lymphocytes. J. Immunol., 190:6173-6179.
  • Lee, J. K., Won, C., Yi, E. H., Seok, S. H., Kim, M. H., Kim, S. J., Chung, M. H., Lee, H. G., Ikuta., K., and Ye, S. K. (2013). Signal transducer and activator of transcription 3 (Stat3) contributes to T-cell homeostasis by regulating pro-survival Bcl-2 family genes. Immunol., 140:288-300.
  • Hanazawa, A., Hayashizaki, K., Shinoda, K., Yagita, H., Okumura, K., Lohning, M., Hara, T., Tani-ichi, S., Ikuta., K., Eckes, B., Radbruch, A., Tokoyoda, K., and Nakayama, T. (2013). CD49b-dependent establishment of T helper cell memory. Immunol. Cell Biol., 91:524-531.
  • Tsuneto, M., Tokoyoda, K., Kajikhina, E., Hauser, A. E., Hara, T., Tani-ichi, S., Ikuta., K., and Melchers, F. (2013).
    B cell progenitors and precursors change their microenvironment in fetal liver during early development. Stem Cells, 31:2800-2812.

2012

  • Hara, T., Shitara, S., Imai, K., Miyachi, H., Kitano, S., Yao, H., Tani-ichi, S., and Ikuta, K. (2012). Identification of interleukin-7-producing cells in primary and secondary lymphoid organs using IL-7-GFP knock-in mice. J. Immunol., 189:1577-1584.
  • Liang, B., Hara, T., Wagatsuma, K., Zhang, J., Maki, K., Miyachi, H., Kitano, S., Yabe-Nishimura, C., Tani-ichi, S., and Ikuta, K. (2012). Role of hepatocyte-derived IL-7 in maintenance of intrahepatic NK T and T cells and development of B cells in fetal liver. J. Immunol., 189:4444-4450.

2011

  • Shinohara, T., Nemoto, Y., Kanai, T., Kameyama, K., Okamoto, R., Tsuchiya, K., Nakamura, T., Totsuka, T., Ikuta, K., and Watanabe, M. (2011). Upregulated IL-7Rα expression on colitogenic memory CD4+ T cells may participate in the development and persistence of chronic colitis. J. Immunol., 186:2623-2632.
  • Ma, Y., Aymeric, L., Locher, C., Mattarollo, S. R., Delahaye, N. F., Pereira, P., Boucontet, L., Apetoh, L., Ghiringhelli, F., Casares, N., Lasarte, J. J., Matsuzaki, G., Ikuta, K., Ryffel, B., Benlagha, K., Tesniere, A., Ibrahim, N., Dechanet-Merville, J., Chaput, N., Smyth, M. J., Kroemer, G., and Zitvogel, L. (2011). Contribution of IL-17-producing γδ T cells to the efficacy of anticancer chemotherapy. J. Exp. Med., 208:491-503.
  • Tani-ichi, S., Satake, M., and Ikuta, K. (2011). The pre-TCR signal induces transcriptional silencing of the TCRγ locus by reducing the recruitment of STAT5 and Runx to transcriptional enhancers. Int. Immunol., 23:553-563.

2010

  • Yoshida, Y.O., Umemura, M., Yahagi, A., O'Brien, R. L., Ikuta, K., Kishihara, K., Hara, H., Nakae, S., Iwakura, Y., and Matsuzaki, G. (2010). Essential role of interleukin-17A in the formation of a mycobacterial infection-induced granuloma in the lung. J. Immunol., 184:4414-4422.
  • Tani-ichi, S., Lee, H.-C., Ye, S.-K., and Ikuta, K. (2010). Accessibility control of TCR Vγ region by STAT5. Int. Immunol., 22:693-703.

2009

  • Tokuriki, A., Iyoda, T., Inaba, K., Ikuta, K., Fujimoto, S., Kumakiri, M., and Yokota, Y. (2009). Dual role for Id2 in chemical carcinogen-induced skin tumorigenesis. Carcinogenesis, 30:1645-1650.
  • Tani-ichi, S., Satake, M., and Ikuta, K. (2009). Activation of the mouse T cell receptor γ enhancers by STAT5. Int. Immunol., 21:1079-1088.
  • Ikuta, K. and Tani-ichi, S. (2009). Role of the IL-7 receptor in γδ T-cell development from hematopoietic stem cells. In "Hematopoietic Stem Cell Biology". Kondo, M., ed. Humana Press Inc. pp143-159.

2008

  • Masui, N., Tani-ichi, S., Maki, K., and Ikuta, K. (2008). Transcriptional activation of mouse TCR Jγ4 germline promoter by Stat5. Mol. Immunol., 45:849-855.
  • Toda, T., Wada, H., Ogawa, S., Tani-ichi, S., and Ikuta, K. (2008). An efficient reporter assay for Stat5-dependent promoters. Anal. Biochem., 372:250-252.
  • Ogawa, S., Satake, M., and Ikuta, K. (2008). Physical and functional interactions between STAT5 and Runx transcriptional factors. J. Biochem., 143:695-709.
  • Maki, K. and Ikuta, K. (2008). MEK1/2 induces STAT5-mediated germline transcription of the TCRγ locus in response to IL-7R signaling. J. Immunol., 181:494-502.
  • Lee, H.-C., Headley, M. B., Iseki, M., Ikuta, K., and Ziegler, S. F. (2008). Inhibition of NF-κB-mediated TSLP expression by retinoid X receptor. J. Immunol., 181:5189-5193.
  • Hamada, S., Umemura, M., Shiono, T., Tanaka, K., Yahagi, A., Begum, M. D., Oshiro, K., Okamoto, Y., Watanabe, H., Kawakami, K., Roark, C., Born, W. K., O'Brien, R., Ikuta, K., Ishikawa, H., Nakae, S., Iwakura, Y., Ohta, T., and Matsuzaki, G. (2008). IL-17A produced by γδ T cells plays a critical role in innate immunity against Listeria monocytogenes infection in the liver. J. Immunol., 181:3456-3463.

2007

  • Nakasone, C., Yamamoto, N., Nakamatsu, M., Kinjo, T., Miyagi, K., Uezu, K., Nakamura, K., Higa, F., Ishikawa, H., O'Brien, R. L., Ikuta, K., Kaku, M., Fujita, J., and Kawakami, K. (2007). Accumulation of gamma/delta T cells in the lungs and their roles in neutrophil-mediated host defense against pneumococcal infection. Microbes Infect., 9:251-258.
  • Shibata, H., Tani-ichi, S., Lee, H.-C., Maki, K., and Ikuta, K. (2007). Induction of the IL-7 receptor α chain in mouse peripheral B cells by glucocorticoids. Immunol. Lett., 111:45-50.

2006

  • Simonian, P. L., Roark, C. L., del Valle, F. D., Palmer, B. E., Douglas, I. S., Ikuta, K., Born, W. K., O'Brien, R. L., and Fontenot, A. P. (2006). Regulatory role of γδ cells in the recruitment of CD4+ and CD8+ T cells to lung and subsequent pulmonary fibrosis. J. Immunol., 177:4436-4443.

2005

  • Ye, S. K., Kim, T. J, Won, S. S., Yoon, T. J., Park, T. K., Yoo, Y. C., Kim, Y. N., Lee, H. C., Ikuta, K., Chung, M. H., Lee, K. H. (2005). Transcriptional regulation of the mouse interleukin-2 receptor β chain gene by Ets and Egr-1. Biochem. Biophys. Res. Commun., 329:1094-1101.
  • Lee, H.-C., Shibata, H., Ogawa, S., Maki, K., and Ikuta, K. (2005). Transcriptional regulation of the mouse IL-7 receptor α promoter by glucocorticoid receptor. J. Immunol., 174:7800-7806.

2004

  • Gomez-del Arco, P., Maki, K., and Georgopoulos, K. (2004). Phosphorylation controls Ikaros's ability to negatively regulate the G1-S transition. Mol. Cell. Biol., 24: 2797-2807.

2003

  • Watanabe, N., Ikuta, K., Okazaki, K., Nakase, H., Tabata, Y., Matsuura, M., Tamaki, H., Kawanami, C., Honjo, T., and Chiba, T. (2003). Elimination of local macrophages in intestine prevents chronic colitis in interleukin-10 deficient mice. Dig. Dis. Sci., 48:408-418.
  • Kim-Saijo, M., Akamizu, T., Ikuta, K., Iida, Y., Ohmori, K., Matsubara, K., Matsuda, Y., Suzuki, M., Matsuda, F., and Nakao, K. (2003). Generation of a transgenic animal model of hyperthyroid Graves' disease. Eur. J. Immunol., 33:2531-2538.

2002

  • Lee, H.-C., Tomiyama, K., Ye, S.-K., Kawai, K., and Ikuta, K. (2002). Seeding of dendritic epidermal T cells in the neonatal skin is reduced in 129 strain of mice. Immunol. Lett., 81:211-216.
  • Han, H., Tanigaki, K., Yamamoto, N., Kuroda, K., Yoshimoto, M., Nakahata, T., Ikuta, K., and Honjo, T. (2002). Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision. Int. Immunol., 14:637-645.
  • Watanabe, N., Ikuta, K., Nisitani, S., Chiba, T., and Honjo, T. (2002). Activation and differentiation of autoreactive B-1 cells by interleukin-10 induce autoimmune hemolytic anemia in Fas-deficient anti-erythrocyte immunoglobulin transgenic mice. J. Exp. Med., 196:141-146.
  • Lahn, M., Kanehiro, A., Takeda, K., Terry, J., Hahn, Y. S., Aydintug, M. K., Konowal, A., Ikuta, K., O'Brien, R. L., Gelfand, E. W., and Born, W. K. (2002). MHC class I-dependent Vγ4+ pulmonary T cells regulate αβ T cell-independent airway responsiveness. Proc. Natl. Acad. Sci. USA., 99:8850-8855.

2001

  • Honda, K., Nakano H., Yoshida, H., Nishikawa, S., Rennert, P., Ikuta, K., Tamechika, M., Yamaguchi, K., Fukumoto, T., Chiba, T., and Nishikawa, S.-I. (2001). Molecular basis for hematopoietic/mesenchymal interaction during initiation of Peyer's patch organogenesis. J. Exp. Med., 193:621-630.
  • Agata, Y., Katakai, T., Ye, S.-K., Sugai, M., Gonda, H., Honjo, T., Ikuta, K., and Shimizu, A. (2001). Histone acetylation determines the developmentally regulated accessibility for T cell receptor-γ gene recombination. J. Exp. Med., 193:873-879.
  • Ikuta. K., Lee, H.-C., and Ye, S.-K. (2001). Role of the IL-7 receptor in γδ T cell development. In "Gamma-delta T cells", Bergstresser, P. R., and Takashima, A., (eds). Chem. Immunol., 79:29-42.
  • Lee, H.-C., Ye, S.-K., Honjo, T., and Ikuta, K. (2001). Induction of germline transcription in the human T cell receptor γ locus by STAT5. J. Immunol., 167:320-326.
  • Ohba, Y., Ikuta, K., Ogura, A., Matsuda, J., Mochizuki, N., Nagashima, K., Kurokawa, K., Mayer, B. J., Maki, K., Miyazaki, J., and Matsuda, M. (2001). Requirement for C3G-dependent Rap1 activation for cell adhesion and embryogenesis. EMBO J., 20:3333-3341.
  • Ye, S.-K., Maki, K., Lee, H.-C., Ito, A., Kawai, K., Suzuki, H., Mak, T. W., Chien, Y., Honjo, T., and Ikuta, K. (2001). Differential roles of cytokine receptors in the development of epidermal γδ T cells. J. Immunol., 167:1929-1934.
  • Fagarasan, S., Kinoshita, K., Muramatsu, M., Ikuta, K., and Honjo, T. (2001). In situ class switching and differentiation to IgA-producing cells in the gut lamina propria. Nature, 413:639-643.
  • Ye, S.-K., Agata, Y., Lee, H.-C., Kurooka, H., Kitamura, T., Shimizu, A., Honjo, T., and Ikuta, K. (2001). The IL-7 receptor controls the accessibility of the TCRγ locus by Stat5 and histone acetylation. Immunity, 15:813-823.

2000

  • Kina, T., Ikuta, K., Takayama, E., Wada, K., Majumdar, A. S., Weissman, I. L. and Katsura, Y. (2000). The monoclonal antibody TER-119 recognizes a molecule associated with glycophorin A and specifically marks the late stages of murine erythroid lineage. Brit. J. Heamatol., 109:280-287.
  • Fagarasan, S., Shinkura, R., Kamata, T., Nogaki, F., Ikuta, K., Tashiro, K., and Honjo, T. (2000). Alymphoplasia(aly)-type nuclear factor κB-inducing kinase (NIK) causes defects in secondary lymphoid tissue chemokine receptor signaling and homing of peritoneal cells to the gut-associated lymphatic tissue system. J. Exp. Med., 191:1477-1486.
  • Kamata, T., Nogaki, F., Fagarasan, S., Sakiyama, T., Kobayashi, I., Miyawaki, S., Ikuta, K., Muso, E., Yoshida, H., Sasayama, S., and Honjo, T. (2000). Increased frequency of surface IgA-positive plasma cells in the intestinal lamina propria and decreased IgA excretion in hyper IgA (HIGA) mice, a murine model of IgA nephropathy with hyperserum IgA. J. Immunol., 165:1387-1394.
  • Watanabe, N., Ikuta, K., Fagarasan, S., Yazumi, S., Chiba, T., and Honjo, T. (2000). Migration and differentiation of autoreactive B-1 cells induced by activated γδ T cells in anti-erythrocyte immunoglobulin transgenic mice. J. Exp. Med., 192:1577-1586.
  • Fagarasan, S., Shinkura, R., Kamata, T., Nogaki, F., Ikuta, K., and Honjo, T. (2000). Mechanism of B1 cell differentiation and migration in GALT. In "B1 lymphocytes in B cell neoplasia". Potter, M., and Melchers, F. eds. Cur. Top. Microbiol. Immunol., vol. 252. pp221-229.
  • O'Brien, R. L., Yin, X., Huber, S. A., Ikuta, K., and Born, W. K. (2000). Depletion of a γδ T cell subset can increase host resistance to a bacterial infection. J. Immunol., 165:6472-6479.