主要論文リスト(2005年〜現在)

全ての論文リストはこちらを参照して下さい。

 

Kaise T, Kageyama R (2021)

Hes1 oscillation frequency correlates with activation of neural stem cells

Gene Expr Patterns DOI: 10.1016/j.gep.2021.119170

 

Ohtsuka T, Kageyama R (2021)

Hes1 overexpression leads to expansion of embryonic neural stem cell pool and stem cell reservoir in the postnatal brain

Development 17;148(4):dev189191.doi: 10.1242/dev.189191.

 

Yoshioka-Kobayashi K, Kageyama R (2020)

Imaging and manipulating the segmentation clock.

Cell Mol Life Sci 78(4):1221-1231.doi: 10.1007/s00018-020-03655-z.

 

Kobayashi T, Kageyama R (2020)

Lysosomes and signaling pathways for maintenance of quiescence in adult neural stem cells.

FEBS J. 26;147(4):dev182204. 288(10):3082-3093. doi: 10.1111/febs.15555.

 

Ochi S, Imaizumi Y, Shimojo H, Miyachi H, Kageyama R (2020)

Oscillatory expression of Hes1 regulates cell proliferation and neuronal differentiation in the embryonic brain.

Development. 26;147(4):dev182204. doi: 10.1242/dev.182204.

 

Yoshioka-Kobayashi K, Matsumiya M, Niino Y, Isomura A, Kori H, Miyawaki A, Kageyama R (2020)

Coupling delay controls synchronized oscillation in the segmentation clock.

Nature. 580(7801):119-123. doi: 10.1038/s41586-019-1882-z

 

Takagi A, Isomura A, Yoshioka-Kobayashi K, Kageyama R (2020)

Dynamic Delta-like1 expression in presomitic mesoderm cells during somite segmentation.

Gene Expr Patterns. doi: 10.1016/j.gep.2019.119094.

 

Shimojo H, Kageyama R (2019)

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis.

J Vis Exp. doi: 10.3791/60455.

 

Sakamoto S, Tateya T, Omori K, Kageyama R (2019)

Idgenes are required for morphogenesis and cellular patterning in the developing mammalian cochlea.

Dev Biol. 15;460(2):164-175. doi: 10.1016/j.ydbio.2019.12.006.

 

Kobayashi T, Piao W, Takamura T, Kori H, Miyachi H, Kitano S, Iwamoto Y, Yamada M, Imayoshi I, Shioda S, Ballabio A, Kageyama R (2019)

Enhanced lysosomal degradation maintains the quiescent state of neural stem cells.

Nat Commun. doi: 10.1038/s41467-019-13203-4.

 

Tateya T, Sakamoto S, Ishidate F, Hirashima T, Imayoshi I, Kageyama R (2019)

Three-dimensional live imaging of Atoh1 reveals the dynamics of hair cell induction and organization in the developing cochlea.

Development. doi: 10.1242/dev.177881.

 

Sueda R, Kageyama R (2019)

Regulation of active and quiescent somatic stem cells by Notch signaling.

Dev Growth Differ. doi: 10.1111/dgd.12626.

 

Vissers C, Kageyama R (2019)

Bursting the Notch Bubble: New Insights into In Vivo Transcriptional Dynamics.

Dev Cell. doi: 10.1016/j.devcel.2019.07.028.

 

Matsuzaki T, Yoshihara T, Ohtsuka T, Kageyama R (2019)

Hes1 expression in mature neurons in the adult mouse brain is required for normal behaviors.

Sci Rep. doi: 10.1038/s41598-019-44698-y.

 

Sueda R, Imayoshi I, Harima Y, Kageyama R (2019)

High Hes1 expression and resultant Ascl1 suppression regulate quiescent vs. active neural stem cells in the adult mouse brain.

Genes Dev. doi: 10.1101/gad.323196.118.

 

Ohtsuka T, Kageyama R (2019)

Regulation of temporal properties of neural stem cells and transition timing of neurogenesis and gliogenesis during mammalian neocortical development.

Semin Cell Dev Biol. doi: 10.1016/j.semcdb.2019.01.007.

 

Kageyama R, Shimojo H, Ohtsuka T. (2018)

Dynamic control of neural stem cells by bHLH factors.

Neurosci Res.doi:10.1016/j.neures.2018.09.005.[Epub ahead of print]

 

Kageyama R, Shimojo H, Isomura A. (2018)

Oscillatory Control of Notch Signaling in Development.

Adv Exp Med Biol. (1066) 265-277

 

Isomura A, Kageyama R.(2018)

An Optogenetic Method to Control and Analyze Gene Expression Patterns in Cell-to-cell Interactions.

J Vis Exp. (133) doi: 10.3791/57149

 

Matsumiya M, Tomita T, Yoshioka-Kobayashi K, Isomura A, Kageyama R.(2018)

ES cell-derived presomitic mesoderm-like tissues for analysis of synchronized oscillations in the segmentation clock.

Development.145(4), dev.156836

 

Isomura A, Kageyama R.(2017)

Illuminating information transfer in signaling dynamics by optogenetics.

Curr Opin Cell Biol.49, 9-15

 

Isomura A, Kori H, Kageyama R.(2017)

Segmentation Genes Enter an Excited State.

Dev Cell.43(2), 121-123

 

Bansod S, Kageyama R, Ohtsuka T.(2017)

Hes5 regulates the transition timing of neurogenesis and gliogenesis in mammalian neocortical development.

Development.144(17), 3156-3167

 

Isomura A, Ogushi F, Kori H, Kageyama R.(2017)

Optogenetic perturbation and bioluminescence imaging to analyze cell-to-cell transfer of oscillatory information.

Genes Dev.31(5), 524-535

 

Shimojo H, Kageyama R.(2016)

Oscillatory control of Delta-like1 in somitogenesis and neurogenesis: A unified model for different oscillatory dynamics.

Semin Cell Dev Biol. 49, 76-82(Review)

 

Shimojo H, Isomura A, Ohtsuka T, Kori H, Miyachi H, Kageyama R.(2016)

Oscillatory control of Delta-like1 in cell interactions regulates dynamic gene expression and tissue morphogenesis.

Genes Dev. 30(1), 102-16

 

Imayoshi I, Ishidate F, Kageyama R.(2015)

Real-time imaging of bHLH transcription factors reveals their dynamic control in the multipotency and fate choice of neural stem cells.

Front Cell Neurosci. 9, 288(Review)

 

Tateya T, Sakamoto S, Imayoshi I, Kageyama R.(2015)

In vivo overactivation of the Notch signaling pathway in the developing cochlear epithelium.

Hear Res. 327, 209-17

 

Watanabe N, Kageyama R, Ohtsuka T.(2015)

Hbp1 regulates the timing of neuronal differentiation during cortical development by controlling cell cycle progression.

Development. 142(13), 2278-90

 

Kobayashi T, Iwamoto Y, Takashima K, Isomura A, Kosodo Y, Kawakami K, Nishioka T, Kaibuchi K, Kageyama R.(2015)

Deubiquitinating enzymes regulate Hes1 stability and neuronal differentiation.

FEBS J. 282(13), 2411-23

 

Isomura A, Kageyama R.(2014)

Ultradian oscillations and pulses: coordinating cellular responses and cell fate decisions.

Development. 141(19), 3627-36(Review)

 

Kobayashi T, Kageyama R.(2014)

Expression dynamics and functions of Hes factors in development and diseases.

Curr Top Dev Biol. 110, 263-83(Review)

 

Imayoshi I, Kageyama R.(2014)

Oscillatory control of bHLH factors in neural progenitors.

Trends Neurosci. 37(10), 531-8(Review)

 

Shimojo H, Harima Y, Kageyama R.(2014)

Visualization of Notch signaling oscillation in cells and tissues.

Methods Mol Biol.1187,169-79(Review)

 

Harima Y, Imayoshi I, Shimojo H, Kobayashi T, Kageyama R.(2014)

The roles and mechanism of ultradian oscillatory expression of the mouse Hes genes.

Semin Cell Dev Biol.(34), 85-90(Review)

 

Kageyama R, Shimojo H, Imayoshi I.(2014)

Dynamic expression and roles of Hes factors in neural development.

Cell Tissue Res.359(1), 125-33(Review)

 

Sakamoto M, Ieki N, Miyoshi G, Mochimaru D, Miyachi H, Imura T, Yamaguchi M, Fishell G, Mori K, Kageyama R, Imayoshi I.(2014)

Continuous postnatal neurogenesis contributes to formation of the olfactory bulb neural circuits and flexible olfactory associative learning.

J Neurosci. 34(17), 5788-99

 

Imayoshi I, Kageyama R.(2014)

bHLH Factors in Self-Renewal, Multipotency, and Fate Choice of Neural Progenitor Cells.

Neuron. 82(1), 9-23(Review)

 

Imayoshi I, Isomura A, Harima Y, Kawaguchi K, Kori H, Miyachi H, Fujiwara T, Ishidate F, Kageyama R.(2013)

Oscillatory Control of Factors Determining Multipotency and Fate in Mouse Neural Progenitors.

Science. 342(6163), 1203-8

[プレスリリース][ライフサイエンス新着論文レビュー

 

Tateya T, Imayoshi I, Tateya I, Hamaguchi K, Torii H, Ito J, Kageyama R.(2013)

Hedgehog signaling regulates prosensory cell properties during the basal-to-apical wave of hair cell differentiation in the mammalian cochlea.

Development. 140, 3848-3857

 

Harima Y, Kageyama R.(2013)

Oscillatory links of Fgf signaling and Hes7 in the segmentation clock.

Curr Opin Genet Dev. 23(4), 484-490 (Review)

 

González A, Manosalva I, Liu T, Kageyama R.(2013)

Control of Hes7 Expression by Tbx6, the Wnt Pathway and the Chemical Gsk3 Inhibitor LiCl in the Mouse Segmentation Clock.

PLoS ONE 8(1): e53323.doi:10.1371/journal.pone.0053323

 

Manosalva I, González A, Kageyama R.(2013)

Hes1 in the somatic cells of the murine ovary is necessary for oocyte survival and maturation.

Dev Biol. 375(2), 140-151

 

Harima Y, Takashima Y, Ueda Y, Ohtsuka T, Kageyama R.(2013)

Accelerating the tempo of the segmentation clock by reducing the number of introns in the hes7 gene.

Cell Rep. 3, 1-7プレスリリース

 

Tan, S.-L., Ohtsuka, T., González, A., and Kageyama, R. (2012) MicroRNA9 regulates neural stem cell differentiation by controlling Hes1 expression dynamics in the developing brain.

Genes to Cells 17, doi: 10.1111/gtc.12009

 

Tan, S.-L., Nishi, M., Ohtsuka, T., Matsui, T., Takemoto, K., Kamio-Miura, A., Aburatani, H., Shinkai, Y., Kageyama, R.(2012)

Essential roles of the histone methyltransferase ESET in the epigenetic control of neural progenitor cells during development.

Development 139, 3806-3816.

 

Kageyama, R., Niwa, Y., Isomura, A., González, A., and Harima, Y. (2012)

Oscillatory gene expression and somitogenesis.

WIREs Dev Biol 1, doi: 10.1002/wdev.46 (Review)

 

Ueo, T., Imayoshi, I., Kobayashi, T., Ohtsuka, T., Seno, H., Nakase, H., Chiba, T., and Kageyama, R. (2012)

The role of Hes genes in intestinal development, homeostasis and tumor formation.

Development 139, 1071-1082.

 

Ohtsuka, T., Shimojo, H., Matsunaga, M., Watanabe, N., Kometani, K., Minato, N., and Kageyama, R. (2011)

Gene expression profiling of neural stem cells and identification of regulators fo neural differentiation during cortical developmet.

Stem Cells 29, 1817-1828.

 

Niwa, Y., Shimojo, H., Isomura, A., González, A., Miyachi, H., and Kageyama R. (2011)

Different types of oscillations in Notch and Fgf signaling regulate the spatiotemporal periodicity of somitogenesis.

Genes Dev 25, 1115-1120.

 

Sakamoto, M., Imayoshi, I., Ohtsuka, T., Yamaguchi, M., Mori, K., and Kageyama, R. (2011)

Continuous neurogenesis in the adult forebrain is required for innate olfactory responses.

Proc Natl Acad Sci U S A 108, 8479-8484.プレスリリース

 

Takashima, Y., Ohtsuka, T., González, A., Miyachi, H., and Kageyama, R. (2011) Intronic delay is essential for oscillatory expression in the segmentation clock.

Proc Natl Acad Sci U S A 108, 3300-3305.

 

Tateya, T., Imayoshi, I., Tateya, I., Ito, J., and Kageyama, R. (2011) Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development.

Dev Biol 352, 329-340.

 

Imayoshi, I., Sakamoto, M., Yamaguchi, M., Mori, K., and Kageyama, R. (2010)

Essential roles of Notch signaling in maintenance of neural stem cells in the developing and adult brains.

J Neurosci. 30, 3489-3498.

 

Kobayashi, T., Mizuno, H., Imayoshi, I., Furusawa, C., Shirahige, K., and Kageyama, R. (2009)

The cyclic gene Hes1 contributes to diverse differentiation responses of embryonic stem cells.

Genes Dev. 23, 1870-1875.プレスリリース


Kageyama, R., Ohtsuka, T., Shimojo, H., and Imayoshi, I. (2008)
Dynamic Notch signaling in neural progenitor cells and a revised view of lateral inhibition.

Nature Neurosci. 11, 1247-1251.


Imayoshi, I., Sakamoto, M., Ohtsuka, T., Takao, K., Miyakawa, T., Yamaguchi, M., Mori, K., Ikeda, T., Itohara, S., and Kageyama, R. (2008) Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain.

Nature Neurosci. 11, 1153-1161. プレスリリース

 

Imayoshi, I., Shimogori, T., Ohtsuka, T., and Kageyama, R. (2008)

Hes genes and neurogenin regulate non-neural versus neural fate specification in the dorsal telencephalic midline.

Development 135, 2531-2541.

 

Shimojo, H., Ohtsuka, T., and Kageyama, R. (2008)

Oscillations in Notch signaling regulate maintenance of neural progenitors.

Neuron,58(1), 52-64.プレスリリース

 

Niwa, Y., Masamizu, Y., Liu, T., Nakayama, R., Deng, C.-X., and Kageyama, R. (2007)

The initiation and propagation of Hes7 oscillation are cooperatively regulated by Fgf and Notch signaling in the somite segmentation clock.

Dev. Cell 13, 298-304.プレスリリース

 

Yoshiura, S., Ohtsuka, T., Takenaka, Y., Nagahara, H., Yoshikawa, K., and Kageyama, R. (2007)

Ultradian oscillations in Stat, Smad and Notch signaling pathways in response to serum.

Proc. Natl. Acad. Sci. U S A 104, 11292-11297.プレスリリース


Baek, J.H., Hatakeyama, J., Sakamoto, S., Ohtsuka, T., and Kageyama, R. (2006)

Persistent and high levels of Hes1 expression regulate boundary formation in the developing central nervous system.

Development 133, 2467-2476.

 

Masamizu, Y., Ohtsuka, T., Takashima, Y., Nagahara, H., Takenaka, Y., Yoshikawa, K., Okamura, H., and Kageyama, R. (2006)

Real-time imaging of the somite segmentation clock: revelation of unstable oscillators in the individual presomitic mesoderm cell.

Proc. Natl. Acad. Sci. U S A 103, 1313-1318.

 

Ohsawa, R., Ohtsuka, T., and Kageyama, R. (2005)

Mash1 and Math3 are required for development of branchiomotor neurons and maintenance of neural progenitors.

J. Neurosci.25, 5857-5865.