Welcome to Toyoshima Lab
Balance between self-renewal and differentiation of stem cells is essential for tissue homeostasis. Biased stem cell self-renewal or differentiation leads to changes in tissue organization and in organ size. Our group focuses on the mechanisms of symmetric/asymmetric stem cell division, stem cell differentiation, stem cell plasticity, and cell lineage-commitment in tissue homeostasis and regeneration. We are interested in how tissue stem cells adapt to physiological changes of the body throughout the life stages of adulthood, such as pregnancy, obesity and aging.
Interfollicular epidermal stem cell dynamics during pregnancy
During pregnancy, the maternal abdominal skin rapidly expands to accommodate fetal growth. We identify the highly proliferative IFE stem cell progenies that are necessary for skin expansion during the course of gestation. The pregnancy-associated IFE stem cell dynamics is induced by proteins secreted from dermal cells.