Lab. of Tissue Homeostasis, Department of Biosystems Science

Institute for Frontier and Medical Sciences, Kyoto University

Lab. of Cell Division and Differentiation, Department of Mammalian Regulatory Network

Graduate School of Biostudies, Kyoto University

Toyoshima Lab

Welcome to Toyoshima Lab

Balance between self-renewal and differentiation of stem cells is essential for tissue homeostasis. Biased stem cell self-renewal or differentiation leads to changes in tissue organization and in organ size. Our group focuses on the mechanisms of symmetric/asymmetric stem cell division, stem cell differentiation, stem cell plasticity, and cell lineage-commitment in tissue homeostasis and regeneration. We are interested in how tissue stem cells adapt to physiological changes of the body throughout the life stages of adulthood, such as pregnancy, obesity and aging.

Recent highlights

Interfollicular epidermal stem cell dynamics during pregnancy

During pregnancy, the maternal abdominal skin rapidly expands to accommodate fetal growth. We identify the highly proliferative IFE stem cell progenies that are necessary for skin expansion during the course of gestation. The pregnancy-associated IFE stem cell dynamics is induced by proteins secreted from dermal cells.

Ichijo et al., Nature Communications 8: 508, 2017 DOI: 10.1038/s41467-017-00433-7

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