Lab. of Tissue Homeostasis, Department of Biosystems Science

Institute for Frontier and Medical Sciences, Kyoto University


Lab. of Cell Division and Differentiation, Department of Mammalian Regulatory Network

Graduate School of Biostudies, Kyoto University

Toyoshima Lab

Publications

Riki Ishibashi, Ritsuko Maki, Satsuki Kitano, Hitoshi Miyachi, Fumiko Toyoshima.

Development of an in vivo cleavable donor plasmid for targeted transgene integration by CRISPR-Cas9 and CRISPR-Cas12a.

Sci. Rep. (2022) https://doi.org/10.1038/s41598-022-22639-6

 

Ryo Ichijo, Koichiro Maki, Mio Kabata, Teruasa Murata, Arata Nagasaka, Seiichiro Ishihara, Hisashi Haga, Tetsuya Honda, Taiji Adachi, Takuya Yamamoto, Fumiko Toyoshima.

Vasculature atrophy causes a stiffened microenvironment that augments epidermal stem cell differentiation in aged skin.

Nature Aging. (2022) https://doi.org/10.1038/s43587-022-00244-6

https://rdcu.be/cRpsh

 

Kozuki S, Sakurai S, Suzuki A, Yamamoto T, Toyoshima F.

Delineation of biliary epithelial cell dynamics in maternal liver during pregnancy.

Genes Cells. (2021) https://DOI: 10.1111/gtc.12918.

 

Oda Y., Takahashi C., Harada S., Nakamura S., Sun D., Kiso K., Urata Y., Miyachi H., Fujiyoshi Y., Honigmann A., Uchida S., Ishihama Y. and Toyoshima F.

Discovery of anti-inflammatory physiological peptides that promote tissue repair by reinforcing epithelial barrier formation.

Sci. Adv. 7, 47 (2021) https://DOI: 10.1126/sciadv.abj6895

 

Ichijo R., Kabata M., Kidoya H., Muramatsu F., Ishibashi R. Abe K., Tsutsui K., Kubo H., Iizuka Y., Kitano S., Miyachi H., Kubota Y., Fujiwara H., Sada A., Yamamoto T. and Toyoshima F.

Vasculature-driven stem cell population coordinates tissue scaling in dynamic organs.

Sci. Adv. 7, 7 (2021) https://DOI: 10.1126/sciadv.abd2575

 

Ishibashi R. Abe K., Ido N., Kitano S., Miyachi H., and Toyoshima F.

Genome editing with the donor plasmid equipped with synthetic crRNA-target sequence.

Sci. Rep. 10, 14120 (2020) https://doi.org/10.1038/s41598-020-70804-6

 

Murata, T., Honda, T., Egawa, G., Yamamoto, Y., Ichijo, R., Toyoshima, F., Dainichi, T. and Kabashima, K.

Transient elevation of cytoplasmic calcium ion concentration at a single cell level precedes morphological changes of epidermal keratinocytes during cornification.

Sci. Rep. 8, 6610 (2018) https://doi.org/10.1038/s41598-018-24899-7

 

Ichijo, R., Kobayashi, H., Yoneda, S., Iizuka, Y., Kubo, H., Matsumura, S., Kitano, S., Miyachi, H., Honda, T. and Toyoshima, F.

Tbx3-dependent amplifying stem cell progeny drives interfollicular epidermal expansion during pregnancy and regeneration.

Nat. Commun.8, 508 (2017) https://doi.org/10.1038/s41467-017-00433-7

 

Fukuhara, M., Ma, Y., Nagasawa, K. and Toyoshima, F.

A G-quadruplex structure at the 5' end of the H19 coding region regulates H19 transcription.

Sci. Rep. 8, 45815 (2017) https://doi.org/10.1038/srep45815

 

Ikeda, M. and Toyoshima, F.

Dormant pluripotent cells emerge during neural differentiation of embryonic stem cells in a FoxO3-dependent manner.

Mol. Cell. Biol. 37, e00417-16 (2017) https://doi.org/10.1128/MCB.00417-16

 

Ichijo, R., Iizuka, Y., Kubo, H. and Toyoshima, F.

Essential roles of Tbx3 in embryonic skin development during epidermal stratification.

Gene Cells22, 284-292 (2017) https://doi.org/10.1111/gtc.12476

 

Matsumura, S., Kojidani, T., Kamioka, Y., Uchida, S., Haraguchi, T., Kimura, A. and Toyoshima, F.

Interphase adhesion geometry is transmitted to an internal regulator for spindle orientation via caveolin-1.

Nat. Commun. 7, 11858 (2016) https://doi.org/10.1038/ncomms11858

 

Ishibashi, R., Kozuki, S., Kamakura, S., Sumimoto, H. and Toyoshima, F.

c-Rel Regulates Inscuteable Gene Expression during Mouse Embryonic Stem Cell Differentiation.

J. Biol. Chem. 291, 3333-3345 (2016) https://doi.org/10.1074/jbc.M115.679563

 

Hanafusa, H, Kedashiro, S., Tezuka M., Funatsu, M., Usami, S., Toyoshima, F. and Matsumoto, K.

PLK1-dependent activation of LRRK1 regulates spindle orientation by phosphorylating CDK5RAP2.

Nat. Cell Biol. (2015) https://doi.org/10.1038/ncb3204

 

Iwano, S., Satou, A., Matsumura, S., Sugiyama, N., Ishihama, Y. and Toyoshima, F.

PCTK1 regulates integrin-dependent spindle orientation via PKA regulatory subunit KAP0 and myosin X.

Mol. Cell. Biol. 35, 1197-1208 (2015) https://doi.org/10.1128/MCB.01017-14

 

Hamasaki, M., Matsumura, S., Satou, A., Takahashi, C., Oda, Y., Higashiura, C., Ishihama, Y. and Toyoshima, F.

Pregnenolone functions in centriole cohesion during mitosis.

Chem. Biol. 21, 1707-1721 (2014) https://doi.org/10.1016/j.chembiol.2014.11.005

 

Ikawa, K.,Satou, A., Fukuhara, A., Matsumura, S., Sugiyama, N., Goto, H., Fukuda, M.,Inagaki, M., Ishihama, Y. and Toyoshima, F.

Inhibition of endocytic vesicle fusion by Plk1-mediated phosphorylation of vimentin during mitosis.

Cell Cycle 13, 126-137 (2014) https://doi.org/10.4161/cc.26866

 

Matsumura, S., Hamasaki, M., Yamamoto, T., Ebisuya, M., Sato, M., Nishida, E. and Toyoshima, F.

ABL1 regulates spindle orientation in adherent cells and mammalian skin.

Nat. Commun. 3, 626 (2012) https://doi.org/10.1038/ncomms1634

 

Matsumura, S. and Toyoshima, F.

ABL1 joins the cadre of spindle orientation machinery.

Cell Struct. Funct. 37, 81-87 (2012) https://doi.org/10.1247/csf.12011

 

Mitsushima, M., Aoki, K., Ebisuya, M., Matsumura, S., Yamamoto, T., Matsuda, M., Toyoshima, F. and Nishida, E.

Revolving movement of a dynamic cluster of actin filaments during mitosis.

J Cell Biol. 191, 453-462　(2010) https://doi.org/10.1083/jcb.201007136

 

Mitsushima, M., Toyoshima, F. and Nishida, E.

Dual role of Cdc42 in spindle orientation control in adherent cells.

Mol. Cell. Biol. 29, 2816-2827 (2009) https://doi.org/10.1128/MCB.01713-08

 

Toyoshima, F., Matsumura, S., Morimoto, H., Mitsushima, M. and Nishida, E.

PtdIns(3,4,5)P3 regulates spindle orientation in adherent cells.

Dev. Cell,13, 796-811 (2007) https://doi.org/10.1016/j.devcel.2007.10.014

 

Toyoshima, F. and Nishida, E.

Integrin-mediated adhesion orients the spindle parallel to the substratum in an EB1- and myosin X-dependent manner.

EMBO J. 26, 1487-1498 (2007) https://doi.org/10.1038/sj.emboj.7601599

 

Toyoshima, F. and Nishida, E.

Spindle orientation in animal cell mitosis: roles of integrin in the control of spindle axis.

J. Cell Physiol., 213: 407-411 (2007) https://doi.org/10.1002/jcp.21227

 

Matsumura, S., Toyoshima, F. and Nishida, E.

Polo-like Kinase 1 Facilitates Chromosome Alignment during Prometaphase through BubR1.

J. Biol. Chem., 282: 15217-15227 (2007) https://doi.org/10.1074/jbc.M611053200

 

Nakajima, H., Toyoshima-Morimoto, F., Taniguchi, E. and Nishida, E.

Identification of a consensus motif for Plk1 (Polo-like kinase) phosphorylation reveals Myt1 as a Plk1 substrate.

J. Biol. Chem., 278, 25277-25280 (2003) https://doi.org/10.1074/jbc.C300126200

 

Toyoshima-Morimoto, F., Taniguchi, E. and Nishida, E.

Plk1 promotes nuclear translocation of human Cdc25C during prophase.

EMBO Reports,3, 341-348 (2002) https://doi.org/10.1093/embo-reports/kvf069

 

Taniguchi, E., Toyoshima-Morimoto, F. and Nishida, E.

Nuclear translocation of Plk1 mediated by its bipartite nuclear localization signal.

J. Biol. Chem.,277, 48884-48888 (2002) https://doi.org/10.1074/jbc.M206307200

 

Toyoshima-Morimoto, F., Taniguchi, E., Shinya, N., Iwamatsu, A. and Nishida, E.

Polo-like kinase 1 phosphorylates cyclin B1 and targets it to the nucleus during prophase.

Nature, 410, 215-220 (2001) https://doi.org/10.1038/35065617

 

Toyoshima, F., Moriguchi, T., Wada, A., Fukuda, M. and Nishida, E.

Nuclear export of cyclin B1 and its possible role in the DNA damage G2 checkpoint.

EMBO J., 17, 2728-2735 (1998) https://doi.org/10.1093/emboj/17.10.2728

 

Toyoshima, F., Moriguchi, T. and Nishida, E.

Fas induces cytoplasmic apoptotic responses and activation of the MKK7-JNK/SAPK and MKK6-p38 pathways independent of CPP32-like proteases.

J. Cell Biol., 139, 1005-1015 (1997) https://doi.org/10.1083/jcb.139.4.1005

 

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