The gut contractile organoid: a novel model for studying the gut motility regulated by coordinating signals between interstitial cells of Cajal and smooth muscles photocurable hydrogel.
Yagasaki R, Nakamura R, Shikaya Y, Tadokoro R, Hao R, Wang Z , Eiraku M, Inaba M, Takahashi Y. eLife v1・July 9, 2024
Spatial cell fate manipulation of human pluripotent stem cells by controlling the microenvironment using photocurable hydrogel. Wang Z , Numada A, Wagai F, Oda Y, Ohgushi M, Maki K, Adachi T, Eiraku M.Development 151(6):dev201621, 2024
In vitro induction of patterned branchial arch-like aggregate from human pluripotent stem cells. Seto Y , Ogihara R, Takizawa K, Eiraku M. Nat Commun. 15(1):1351, 2024
RENGE infers gene regulatory networks using time-series single-cell RNA-seq data with CRISPR perturbations.
Ishikawa M, Sugino S, Masuda Y, Tarumoto Y, Seto Y, Taniyama N, Wagai F, Yamaguchi Y, Kojima Y, Kiryu H, Yusa K, Eiraku M, Mochizuki A. Commun Biol 6:1290, 2023
Development of intensiometric indicators for visualizing N-cadherin interaction across cells.
Kanadome T, Hayashi K, Seto Y, Eiraku M, Nakajima K, Nagai T, Matsuda T. Commun Biol 5:1065, 2022
Optogenetic control of apical constriction induces synthetic morphogenesis in mammalian tissues.
Martísnez-Ara G, Taberner N, Takayama M, Sandaltzopoulou E, Villava C, Bosch-Padrós M, Takata N, Trepat X, Eiraku M, Ebisuya M. Nat Commun 13(1): 5400, 2022
Delamination of trophoblast-like syncytia from the amniotic ectodermal analogue in human primed embryonic stem cell-based differentiation model. Ohgushi M, Taniyama N, Vandenbon A, Eiraku M. Cell Reports. 39(12): 110973, 2022
Self-organized formation of developing appendages from murine pluripotent stem cells. Mori S, Sakakura E, Tsunekawa Y, Hagiwara M, Suzuki T, Eiraku M. Nat Commun. 10: 3802, 2019
Medium- to long-term survival and functional examination of human iPSC-derived retinas in rat and primate models of retinal degeneration.
Tu HY, Watanabe T, Shirai H, Yamasaki S, Kinoshita M, Matsushita K, Hashiguchi T, Onoe H, Matsuyama T, Kuwahara A, Kishino A, Kimura T, Eiraku M, Suzuma K, Kitaoka T, Takahashi M, Mandai M. EBioMedicine. 39:562-574, 2019
Strain-triggered mechanical feedback in self-organizing optic-cup morphogenesis.
Okuda S, Takata N, Hasegawa Y, Kawada M, Inoue Y, Adachi T, Sasai Y, Eiraku M.Sci.Adv.4(11):eaau1354, 2018
Establishment of Immunodeficient Retinal Degeneration Model Mice and Functional Maturation of Human ESC-Derived Retinal Sheets after Transplantation.
Iraha S, Tu HY, Yamasaki S, Kagawa T, Goto M, Takahashi R, Watanabe T, Sugita S, Yonemura S, Sunagawa GA, Matsuyama T, Fujii M, Kuwahara A, Kishino A, Koide N, Eiraku M, Tanihara H, Takahashi M, Mandai M.Stem Cell Reports. 10(3):1059-1074, 2018
Combining Turing and 3D vertex models reproduces autonomous multicellular morphogenesis with undulation, tubulation, and branching.
Okuda S, Miura T, Inoue Y, Adachi T, Eiraku M. Sci Rep. 8(1)2386, 2018
An Eye Organoid Approach Identifies Six3 Suppression of R-spondin 2 as a Critical Step in Mouse Neuroretina Differentiation.
Takata N, Abbey D, Fiore L, Acosta S, Feng R, Gil HJ, Lavado A, Geng X, Interiano A, Neale G, Eiraku M, Sasai Y, Oliver G. Cell Rep. 21(6):1534-1549, 2017
Self-patterning of rostral-caudal neuroectoderm requires dual role of Fgf signaling for localized Wnt antagonism.
Takata N, Sakakura E, Eiraku M, Sasukawa T, Sasai Y. Nat Commun. 8(1):1339, 2017
Contractile actin belt and mesh structures provide the opposite dependence of epithelial stiffness on the spontaneous curvature of constituent cells.
Okuda S, Unoki K, Eiraku M, Tsubota K. Dev Growth Differ. 59(5):455-464, 2017
A RHO Small GTPase Regulator ABR Secures Mitotic Fidelity in Human Embryonic Stem Cells.
Ohgushi M, Minaguchi M, Eiraku M, Sasai Y. Stem Cell Reports. 9(1):58-66, 2017
Role of molecular turnover in dynamic deformation of a three-dimensional cellular membrane.
Okuda S. & Eiraku M. Biomech Model Mechanobiol. 16:1805, 2017
Emergence of dorsal-ventral polarity in ES cell-derived retinal tissue.
Hasegawa Y, Takata N, Okuda S, Kawada M, Eiraku M, Sasai Y.Development. 2016 Sep 15. pii: dev.134601. (corresponding author)
Specification of embryonic stem cell-derived tissues into eye fields by Wnt signaling using rostral diencephalic tissue-inducing culture.
Sakakura E, Eiraku M, Takata N.Mech Dev. 141:90-9, 2016
Functional anterior pituitary generated in self-organizing culture of human embryonic stem cells.
Ozone C, Suga H, Eiraku M, Kadoshima T, Yonemura S, Takata N, Oiso Y, Tsuji T, Sasai Y.Nat Commun. 7:10351, 2016
Transplantation of human embryonic stem cell-derived retinal tissue in two primate models of retinal degeneration
Shirai H, Mandai M, Matsushita K, Kuwahara A, Yonemura S, Nakano T, Assawachananont J, Kimura T, Saito K, Terasaki H, Eiraku M, Sasai Y, Takahashi M.
Proc Natl Acad Sci U S A.113(1):E81-90, 2015
Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue.
Sakaguchi H*, Kadoshima T, Soen M, Narii N, Ohgushi M, Takahashi J, Eiraku M, Sasai Y.Nature Communications, 6:8896, 2015 (corresponding author)
Modeling cell apoptosis for simulating three-dimensional multicellular morphogenesis based on a reversible network reconnection framework.
Okuda S, Inoue Y, Eiraku M, Adachi T, Sasai Y.Biomech Model Mechanobiol, sep 11, 2015
Optimized culture system to induce neurite outgrowth from retinal ganglion cells in three dimensional retinal aggregates differentiated from mouse and human embryonic stem cells.
Maekawa Y, Ohnishi A, Matsushita K, Koide N, Mandai M, Suzuma K, Kiaoka T, Kuwahara A, Ozone C, Nakano T, Eiraku M, Takahashi MCurr Eye Res., 19:1-11, 2015
Generation of ciliary margin-like progress zones in human ESC-derived retina with central-peripheral polarity.
Kuwahara A*, Ozone C, Nakano T, Saito K, Eiraku M, Sasai Y Nature Communications, 6:6286, 2015 (corresponding author)
Vertex dynamics simulations of viscosity-dependent deformation during tissue morphogenesis.
Okuda S, Inoue Y, Eiraku M, Adachi T, Sasai Y Biomech Model Mechanobiol., 14:413-425, 2015
Transplantation of embryonic and indued pluripotent stem cell-derived 3D retinal sheets into retinal degenerative mice.
Assawachananont J, Mandai M, Okamoto S, Yamada C, Eiraku M, Yonemura S, Sasai Y, Takahashi M Stem Cell Reports, 2:662-74, 2014
Mechanical control of notochord morphogenesis by extra-embryonic tissues in mouse embryo.
Imuta Y, Koyama H, Shi D, Eiraku M, Fujimori T, Sasaki H Mech Dev., 132:44-58, 2014
Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex.
Kadoshima T, Sakaguchi H, Nakano T, Soen M, Ando S, Eiraku M, Sasai Y. Proc Natl Acad Sci U S A., 110:20284-20289. 2013
Apical contractility in growing epithelium supports robust maintenance of smooth curvatures against cell-division-induced mechanical disturbance.
Okuda S, Inoue Y, Eiraku M, Sasai Y, Adachi T. J Biomech, 46:1705-13, 2013
Robust formation and maintenance of continuous stratified cortical neuroepithelium by laminin-containing matrix in mouse ES cell culture.
Nasu M, Takata N, Danjo T, Sakaguchi H, Kadoshima T, Futaki S, Sekiguchi K, Eiraku M, Sasai Y. PLoS One. 2012;7(12):e53024.
Modeling cell proliferation for simulating three-dimensional tissue morphogenesis based on a reversible network reconnection framework.
Okuda S, Inoue Y, Eiraku M, Sasai Y, Adachi T. Biomech Model Mechanobiol, 12:987-96, 2012
Reversible network reconnection model for simulating large deformation in dynamic tissue morphogenesis.
Okuda S, Inoue Y, Eiraku M, Sasai Y, Adachi T. Biomech Model Mechanobiol, 12:627-44, 2012
Self-formation of optic cups and storable stratified neural retina from human ESCs.
Nakano T, Ando S, Takata N, Kawada M, Muguruma K, Sekiguchi K, Saito K, Yonemura S, Eiraku M, Sasai Y. Cell Stem Cell, 10:771-85, 2012
Mouse ES cell culture for generation of three-dimensional retinal and cortical tissues. Eiraku M and Sasai Y. Nature Protocol, 7:69-79, 2011 (Corresponding author)
Remodeling of monoplanar Purkinje cell dendrites during cerebellar circuit formation.
Kaneko M, Yamaguchi K, Eiraku M, Sato M, Takata N, Kiyohara Y, Mishina M, Hirase H, Hashikawa T, Kengaku M. Plos One, 6:e20108, 2011
Self-organizing optic-cup morphogenesis in three-dimensional culture. Eiraku M, Takata N, Ishibashi H, Kawada M, Sakakura E, Okuda S, Sekiguchi K, Adachi T, Sasai Y. Nature, 472:51-6, 2011 (Corresponding author)
Subregional specification of embryonic stem cell-derived ventral telencephalic tissues by timed and combinatory treatment with extrinsic signals.
Danjo T, Eiraku M, Muguruma K, Watanabe K, Kawada M, Yanagawa Y, Rubenstein JL, Sasai Y. J Neurosci., 31:1919-33, 2011 (Corresponding author)
Molecular pathway and cell state responsible for dissociation-induced apoptosis in human pluripotent stem cells.
Ohgushi M, Matsumura M, Eiraku M, Murakami K, Aramaki T, Nishiyama A, Muguruma K, Nakano T, Suga H, Ueno M, Ishizaki T, Suemori H, Narumiya S, Niwa H, Sasai Y. Cell Stem Cell, 7:225-39, 2010
Self-organized formation of polarized cortical tissues from ES cells and its active manipulation by extrinsic signals. Eiraku M, Watanabe K, Matsuo-Takasaki M, Kawada M, Yonemura S, Matsumura M, Wataya T, Nishiyama A, Muguruma K, Sasai Y. Cell Stem Cell, 3:519-32, 2008
Minimization of exogenous signals in ES cell culture induces rostral hypothalamic differentiation.
Wataya T, Ando S, Muguruma K, Ikeda H, Watanabe K, Eiraku M, Kawada M, Takahashi J, Hashimoto N, Sasai Y. Proc Natl Acad Sci U S A., 105:11796-801, 2008
Receptor type protein tyrosine phosphatase zeta-pleiotrophin signaling controls endocytic trafficking of DNER that regulates neuritogenesis.
Fukazawa N, Yokoyama S, Eiraku M, Kengaku M, Maeda N. Mol Cell Biol., 28:4494-506, 2008
Impaired cerebellar functions in mutant mice lacking DNER.
Tohgo A*, Eiraku M*, Miyazaki T, Miura E, Kawaguchi SY, Nishi M, Watanabe M, Hirano T, Kengaku M, Takeshima H. (*These authors contributed equally to this work) Mol Cell Neurosci., 31:326-33, 2006
DNER acts as a neuron-specific Notch ligand during Bergmann glial development. Eiraku M, Tohgo A, Ono K, Kaneko M, Fujishima K, Hirano T, Kengaku M. Nat Neurosci. 8:873-80, 2005
Dual phases of migration of cerebellar granule cells guided by axonal and dendritic leading processes.
Kawaji K, Umeshima H, Eiraku M, Hirano T, Kengaku M. Mol Cell Neurosci., 25:228-40, 2004
Delta/notch-like epidermal growth factor (EGF)-related receptor, a novel EGF-like repeat-containing protein targeted to dendrites of developing and adult central nervous system neurons. Eiraku M, Hirata Y, Takeshima H, Hirano T, Kengaku M. J Biol Chem., 277:25400-7, 2002
How might we build limbs in vitro informed by the modular aspects and tissue-dependency in limb development?. Tsutsumi R, Eiraku M. Front. Cell Dev. Biol. 11:1135784., 2023
Self-formation of layered neural structures in three-dimensional culture of ES cells. Eiraku M, Sasai Y.Curr Opin Neurobiol, 22:768-77, 2012 (Corresponding author)
Relaxation-expansion model for self-driven retinal morphogenesis: A hypothesis from the perspective of biosystems dynamics at the multi-cellular level.. Eiraku M, Adachi T, Sasai Y Bioessays, 34:17-25, 2012 (Corresponding author)