京都大学 医生物学研究所 生命システム制御部門
発生システム制御分野

海外雑誌-原著論文

• Spatial cell fate manipulation of human pluripotent stem cells by controlling the microenvironment using photocurable hydrogel.
  Wang Z , Numada A, Wagai F, Oda Y, Ohgushi M, Maki K, Adachi T, Eiraku M. Development. 151(6):dev201621, 2024

  PubMed

• In vitro induction of patterned branchial arch-like aggregate from human pluripotent stem cells.
  Seto Y , Ogihara R, Takizawa K, Eiraku M. Nat Commun. 15(1):1351, 2024

  PubMed

  京都大学成果報告ページ

  EurekAlert!

• RENGE infers gene regulatory networks using time-series single-cell RNA-seq data with CRISPR perturbations.
  Ishikawa M, Sugino S, Masuda Y, Tarumoto Y, Seto Y, Taniyama N, Wagai F, Yamaguchi Y, Kojima Y, Kiryu H, Yusa K, Eiraku M, Mochizuki A. Commun Biol 6:1290, 2023

  PubMed

  京都大学成果報告ページ

• Development of intensiometric indicators for visualizing N-cadherin interaction across cells.
  Kanadome T, Hayashi K, Seto Y, Eiraku M, Nakajima K, Nagai T, Matsuda T. Commun Biol 5:1065, 2022

  PubMed

• Optogenetic control of apical constriction induces synthetic morphogenesis in mammalian tissues.
  Martísnez-Ara G, Taberner N, Takayama M, Sandaltzopoulou E, Villava C, Bosch-Padrós M, Takata N, Trepat X, Eiraku M, Ebisuya M. Nat Commun 13(1): 5400, 2022

  PubMed

• Delamination of trophoblast-like syncytia from the amniotic ectodermal analogue in human primed embryonic stem cell-based differentiation model.
  Ohgushi M, Taniyama N, Vandenbon A, Eiraku M. Cell Reports. 39(12): 110973, 2022

  PubMed

• Self-organized formation of developing appendages from murine pluripotent stem cells.
  Mori S, Sakakura E, Tsunekawa Y, Hagiwara M, Suzuki T, Eiraku M. Nat Commun. 10: 3802, 2019

  PubMed

• Medium- to long-term survival and functional examination of human iPSC-derived retinas in rat and primate models of retinal degeneration.
  Tu HY, Watanabe T, Shirai H, Yamasaki S, Kinoshita M, Matsushita K, Hashiguchi T, Onoe H, Matsuyama T, Kuwahara A, Kishino A, Kimura T, Eiraku M, Suzuma K, Kitaoka T, Takahashi M, Mandai M. EBioMedicine. 39:562-574, 2019

  PubMed

• Human brain development and its in vitro recapitulation.
  Seto Y, Eiraku M.Neurosci Res. 138:33-42, 2019

  PubMed

• Strain-triggered mechanical feedback in self-organizing optic-cup morphogenesis.
  Okuda S, Takata N, Hasegawa Y, Kawada M, Inoue Y, Adachi T, Sasai Y, Eiraku M.Sci.Adv.4(11):eaau1354, 2018

  PubMed

• Establishment of Immunodeficient Retinal Degeneration Model Mice and Functional Maturation of Human ESC-Derived Retinal Sheets after Transplantation.
  Iraha S, Tu HY, Yamasaki S, Kagawa T, Goto M, Takahashi R, Watanabe T, Sugita S, Yonemura S, Sunagawa GA, Matsuyama T, Fujii M, Kuwahara A, Kishino A, Koide N, Eiraku M, Tanihara H, Takahashi M, Mandai M.Stem Cell Reports. 10(3):1059-1074, 2018

  PubMed

• Combining Turing and 3D vertex models reproduces autonomous multicellular morphogenesis with undulation, tubulation, and branching.
  Okuda S, Miura T, Inoue Y, Adachi T, Eiraku M. Sci Rep. 8(1)2386, 2018

  PubMed

• An Eye Organoid Approach Identifies Six3 Suppression of R-spondin 2 as a Critical Step in Mouse Neuroretina Differentiation.
  Takata N, Abbey D, Fiore L, Acosta S, Feng R, Gil HJ, Lavado A, Geng X, Interiano A, Neale G, Eiraku M, Sasai Y, Oliver G. Cell Rep. 21(6):1534-1549, 2017

  PubMed

• Self-patterning of rostral-caudal neuroectoderm requires dual role of Fgf signaling for localized Wnt antagonism.
  Takata N, Sakakura E, Eiraku M, Sasukawa T, Sasai Y. Nat Commun. 8(1):1339, 2017

  PubMed

• Stem cells and genome editing: approaches to tissue regeneration and regenerative medicine.
  Takata N, Eiraku M. J Hum Genet. 63(2):165-178, 2017

  PubMed

• Contractile actin belt and mesh structures provide the opposite dependence of epithelial stiffness on the spontaneous curvature of constituent cells.
  Okuda S, Unoki K, Eiraku M, Tsubota K. Dev Growth Differ. 59(5):455-464, 2017

  PubMed

• A RHO Small GTPase Regulator ABR Secures Mitotic Fidelity in Human Embryonic Stem Cells.
  Ohgushi M, Minaguchi M, Eiraku M, Sasai Y. Stem Cell Reports. 9(1):58-66, 2017

  PubMed

• Role of molecular turnover in dynamic deformation of a three-dimensional cellular membrane.
  Okuda S. & Eiraku M. Biomech Model Mechanobiol. 16:1805, 2017

  PubMed

• Emergence of dorsal-ventral polarity in ES cell-derived retinal tissue.
  Hasegawa Y, Takata N, Okuda S, Kawada M, Eiraku M, Sasai Y.Development. 2016 Sep 15. pii: dev.134601. (corresponding author)

  PubMed

• Specification of embryonic stem cell-derived tissues into eye fields by Wnt signaling using rostral diencephalic tissue-inducing culture.
  Sakakura E, Eiraku M, Takata N.Mech Dev. 141:90-9, 2016

  PubMed

• Functional anterior pituitary generated in self-organizing culture of human embryonic stem cells.
  Ozone C, Suga H, Eiraku M, Kadoshima T, Yonemura S, Takata N, Oiso Y, Tsuji T, Sasai Y.Nat Commun. 7:10351, 2016

  PubMed

• Transplantation of human embryonic stem cell-derived retinal tissue in two primate models of retinal degeneration
  Shirai H, Mandai M, Matsushita K, Kuwahara A, Yonemura S, Nakano T, Assawachananont J, Kimura T, Saito K, Terasaki H, Eiraku M, Sasai Y, Takahashi M. Proc Natl Acad Sci U S A.113(1):E81-90, 2015

  PubMed

• Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue.
  Sakaguchi H*, Kadoshima T, Soen M, Narii N, Ohgushi M, Takahashi J, Eiraku M, Sasai Y.Nature Communications, 6:8896, 2015 (corresponding author)

  PubMed

• Modeling cell apoptosis for simulating three-dimensional multicellular morphogenesis based on a reversible network reconnection framework.
  Okuda S, Inoue Y, Eiraku M, Adachi T, Sasai Y.Biomech Model Mechanobiol, sep 11, 2015

  PubMed

• Optimized culture system to induce neurite outgrowth from retinal ganglion cells in three dimensional retinal aggregates differentiated from mouse and human embryonic stem cells.
  Maekawa Y, Ohnishi A, Matsushita K, Koide N, Mandai M, Suzuma K, Kiaoka T, Kuwahara A, Ozone C, Nakano T, Eiraku M, Takahashi MCurr Eye Res., 19:1-11, 2015

  PubMed

• Generation of ciliary margin-like progress zones in human ESC-derived retina with central-peripheral polarity.
  Kuwahara A*, Ozone C, Nakano T, Saito K, Eiraku M, Sasai Y Nature Communications, 6:6286, 2015 (corresponding author)

  PubMed

• Vertex dynamics simulations of viscosity-dependent deformation during tissue morphogenesis.
  Okuda S, Inoue Y, Eiraku M, Adachi T, Sasai Y Biomech Model Mechanobiol., 14:413-425, 2015

  PubMed

• Transplantation of embryonic and indued pluripotent stem cell-derived 3D retinal sheets into retinal degenerative mice.
  Assawachananont J, Mandai M, Okamoto S, Yamada C, Eiraku M, Yonemura S, Sasai Y, Takahashi M Stem Cell Reports, 2:662-74, 2014

  PubMed

• Mechanical control of notochord morphogenesis by extra-embryonic tissues in mouse embryo.
  Imuta Y, Koyama H, Shi D, Eiraku M, Fujimori T, Sasaki H Mech Dev., 132:44-58, 2014

  PubMed

• Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex.
  Kadoshima T, Sakaguchi H, Nakano T, Soen M, Ando S, Eiraku M, Sasai Y. Proc Natl Acad Sci U S A., 110:20284-20289. 2013

  PubMed

• Apical contractility in growing epithelium supports robust maintenance of smooth curvatures against cell-division-induced mechanical disturbance.
  Okuda S, Inoue Y, Eiraku M, Sasai Y, Adachi T. J Biomech, 46:1705-13, 2013

  PubMed

• Robust formation and maintenance of continuous stratified cortical neuroepithelium by laminin-containing matrix in mouse ES cell culture.
  Nasu M, Takata N, Danjo T, Sakaguchi H, Kadoshima T, Futaki S, Sekiguchi K, Eiraku M, Sasai Y. PLoS One. 2012;7(12):e53024.

  PubMed

• Modeling cell proliferation for simulating three-dimensional tissue morphogenesis based on a reversible network reconnection framework.
  Okuda S, Inoue Y, Eiraku M, Sasai Y, Adachi T. Biomech Model Mechanobiol, 12:987-96, 2012

  PubMed

• Reversible network reconnection model for simulating large deformation in dynamic tissue morphogenesis.
  Okuda S, Inoue Y, Eiraku M, Sasai Y, Adachi T. Biomech Model Mechanobiol, 12:627-44, 2012

  PubMed

• Self-formation of optic cups and storable stratified neural retina from human ESCs.
  Nakano T, Ando S, Takata N, Kawada M, Muguruma K, Sekiguchi K, Saito K, Yonemura S, Eiraku M, Sasai Y. Cell Stem Cell, 10:771-85, 2012

  PubMed

• Mouse ES cell culture for generation of three-dimensional retinal and cortical tissues.
  Eiraku M and Sasai Y. Nature Protocol, 7:69-79, 2011 (Corresponding author)

  PubMed

• Remodeling of monoplanar Purkinje cell dendrites during cerebellar circuit formation.
  Kaneko M, Yamaguchi K, Eiraku M, Sato M, Takata N, Kiyohara Y, Mishina M, Hirase H, Hashikawa T, Kengaku M. Plos One, 6:e20108, 2011

  PubMed

• Self-organizing optic-cup morphogenesis in three-dimensional culture.
  Eiraku M, Takata N, Ishibashi H, Kawada M, Sakakura E, Okuda S, Sekiguchi K, Adachi T, Sasai Y. Nature, 472:51-6, 2011 (Corresponding author)

  PubMed

• Subregional specification of embryonic stem cell-derived ventral telencephalic tissues by timed and combinatory treatment with extrinsic signals.
  Danjo T, Eiraku M, Muguruma K, Watanabe K, Kawada M, Yanagawa Y, Rubenstein JL, Sasai Y. J Neurosci., 31:1919-33, 2011 (Corresponding author)

  PubMed

• Molecular pathway and cell state responsible for dissociation-induced apoptosis in human pluripotent stem cells.
  Ohgushi M, Matsumura M, Eiraku M, Murakami K, Aramaki T, Nishiyama A, Muguruma K, Nakano T, Suga H, Ueno M, Ishizaki T, Suemori H, Narumiya S, Niwa H, Sasai Y. Cell Stem Cell, 7:225-39, 2010

  PubMed

• Self-organized formation of polarized cortical tissues from ES cells and its active manipulation by extrinsic signals.
  Eiraku M, Watanabe K, Matsuo-Takasaki M, Kawada M, Yonemura S, Matsumura M, Wataya T, Nishiyama A, Muguruma K, Sasai Y. Cell Stem Cell, 3:519-32, 2008

  PubMed

• Minimization of exogenous signals in ES cell culture induces rostral hypothalamic differentiation.
  Wataya T, Ando S, Muguruma K, Ikeda H, Watanabe K, Eiraku M, Kawada M, Takahashi J, Hashimoto N, Sasai Y. Proc Natl Acad Sci U S A., 105:11796-801, 2008

  PubMed

• Receptor type protein tyrosine phosphatase zeta-pleiotrophin signaling controls endocytic trafficking of DNER that regulates neuritogenesis.
  Fukazawa N, Yokoyama S, Eiraku M, Kengaku M, Maeda N. Mol Cell Biol., 28:4494-506, 2008

  PubMed

• Impaired cerebellar functions in mutant mice lacking DNER.
  Tohgo A*, Eiraku M*, Miyazaki T, Miura E, Kawaguchi SY, Nishi M, Watanabe M, Hirano T, Kengaku M, Takeshima H. (*These authors contributed equally to this work) Mol Cell Neurosci., 31:326-33, 2006

  PubMed

• DNER acts as a neuron-specific Notch ligand during Bergmann glial development.
  Eiraku M, Tohgo A, Ono K, Kaneko M, Fujishima K, Hirano T, Kengaku M. Nat Neurosci. 8:873-80, 2005

  PubMed

• Dual phases of migration of cerebellar granule cells guided by axonal and dendritic leading processes.
  Kawaji K, Umeshima H, Eiraku M, Hirano T, Kengaku M. Mol Cell Neurosci., 25:228-40, 2004

  PubMed

• Delta/notch-like epidermal growth factor (EGF)-related receptor, a novel EGF-like repeat-containing protein targeted to dendrites of developing and adult central nervous system neurons.
  Eiraku M, Hirata Y, Takeshima H, Hirano T, Kengaku M. J Biol Chem., 277:25400-7, 2002

  PubMed

海外雑誌-総説

• How might we build limbs in vitro informed by the modular aspects and tissue-dependency in limb development?.
  Tsutsumi R, Eiraku M. Front. Cell Dev. Biol. 11:1135784., 2023

  DOI

• Toward the formation of neural circuits in human brain organoids.
  Seto Y, Eiraku M. Curr Opin Cell Biol. 61:86-91, 2019

  PubMed

• Stem cells and genome editing: approaches to tissue regeneration and regenerative medicine.
  Takata N, Eiraku M. J Hum Genet, 63(2):165-178, 2018

  PubMed

• In vitro organogenesis in three dimensions: self-organising stem cells.
  Sasai Y, Eiraku M, Suga H.Development, 139:4111-21, 2012

  PubMed

• Self-formation of layered neural structures in three-dimensional culture of ES cells.
  Eiraku M, Sasai Y.Curr Opin Neurobiol, 22:768-77, 2012 (Corresponding author)

  PubMed

• Relaxation-expansion model for self-driven retinal morphogenesis: A hypothesis from the perspective of biosystems dynamics at the multi-cellular level..
  Eiraku M, Adachi T, Sasai Y Bioessays, 34:17-25, 2012 (Corresponding author)

  PubMed

和雑誌-総説

• 瀬戸裕介, 永楽元次,「神経系オルガノイドにおける自発的軸形成」,実験医学(増刊),36(12),2018
• 永楽元次,「神経オルガノイドにおける組織自律的なパターニング機構」,医学のあゆみ,264(8),2018.
• 奥田覚，永楽元次,「眼杯オルガノイド×Computational Biologyーin vitroとin silicoの相補的アプローチ」,実験医学,25(16),2017.
• 永樂元次, 「試験管内での終脳組織分化」, 生体の科学, 68(1), 2017.
• 坂口秀哉, 永樂元次, 「大脳皮質オルガノイド―発生学的観点からの解説とその将来的展望」, 実験医学, 34(17), 2016.
• 奥田覚，永楽元次,「器官をつくる―in vitro眼杯形成モデルと力学シミュレーションによる変形メカニズムの検証」, 実験医学, 33(3), 2015.
• 永樂元次, 「多能性幹細胞からの自律的な網膜組織形成」実験医学, 32(1), 2014
• 長谷川結子,　永樂元次,「三次元培養での自己組織化による眼杯の形態形成」, BIO Clinica, 12月号, 2012
• 永楽元次,「幹細胞の自己組織化による眼杯形成」, 実験医学, 30(10), 2012
• 永樂元次,「in vitroでの三次元神経組織の自己形成とその原理?形と機能を自作する」, 実験医学, 30(2), 2012

その他

• 佐藤俊朗, 武部貴則, 永楽元次,「 開発者座談会：次世代オルガノイド技術で新しい生命像を描け！」,実験医学,37(6),2019

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