京都大学
医学研究科 人間健康科学系専攻 総合医療科学コース

谷一 靖江（共同研究者）Shizue Tani-ichi

谷一 靖江Shizue Tani-ichi

所属

医学研究科 人間健康科学（助教）

学部教育

医学部人間健康科学科の以下の授業に参加しています。

  • 医動物学・微生物学実習（2回生）
  • 病理組織検査学実習（3回生）
  • 臨床化学講義（3回生）
  • 臨床化学実習（3回生）

研究内容

  • 研究室の場所
    医学研究科 人間健康科学系専攻 4F 411/412号室
    ウイルス再生研4号館 2F 201/202/203号室
  • 連絡先
    taniichi.shizue.6m＃kyoto-u.ac.jp（#を@に変えてください）
  • 研究は、ウイルス・再生医科学研究所 生田研究室（免疫制御分野）と共同で行っています。

研究内容はこちら

研究業績

学術雑誌に発表した査読論文

  1. Cui, G., Shimba, A., Ma, G., Takahara, K., Tani-ichi, S., Zhu, Y., Asahi, T., Abe, A., Miyachi, H., Kitano, S., Hara, T., Yasunaga, J., Suwanai, H., Yamada, H., Matsuoka, M., Ueki, K., Yoshikai, Y., and Ikuta, K. (2020). IL-7R-dependent phosphatidylinositol 3-kinase competes with STAT5 signal to modulate T cell development and homeostasis. J. Immunol., 204: 844-857.
  2. Zhu, Y., Cui, G., Miyauchi, E., Nakanishi, Y., Mukohira, H., Shimba, A., Abe, S., Tani-ichi, S., Hara, T., Nakase, H., Chiba, T., Sehara-Fujisawa, A., Seno, H., Ohno, H., and Ikuta, K. (2020). Intestinal epithelial cell-derived IL-15 determines local maintenance and maturation of intraepithelial lymphocytes in the intestine. Int. Immunol., 32: 307-319.
  3. Tani-ichi, S., Wagatsuma, K., Cui, G., Abe, A., Miyachi, H., Kitano, S., Hara, T., and Ikuta, K. (2020). Innate-like CD27+CD45RBhigh γδ T cells require TCR signaling for homeostasis in peripheral lymphoid organs. J. Immunol., 204: 2671-2684.
  4. Rodríguez-Caparrós, A., García, V., Casal, Á, López-Ros, J., García-Mariscal, A., Tani-ichi, S., Ikuta, K., and Hernández-Munain, C. (2019). Notch signaling controls transcription via the recruitment of RUNX1 and MYB to enhancers during T cell development. J. Immunol., 202: 2460-2472.
  5. Mukohira, H., Hara, T., Abe, S., Tani-ichi, S., Sehara-Fujisawa, A., Nagasawa, T., Tobe, K., and Ikuta, K. (2019). Mesenchymal stromal cells in bone marrow express adiponectin and are efficiently targeted by an adiponectin promoter-driven Cre transgene. Int. Immunol., 31: 729-741.
  6. Shimba A, Cui G, Tani-ichi S, Ogawa M, Abe S, Okazaki F, Kitano S, Miyachi H, Yamada H, Hara T, Yoshikai Y, Nagasawa T, Schütz G, and Ikuta K. Glucocorticoids drive diurnal oscillations in T cell distribution and responses by inducing interleukin-7 receptor and CXCR4. Immunity, 48: 286-298, 2018.
  7. Gomes AC, Hara T, Lim VY, Herndler-Brandstetter D, Nevius E, Sugiyama T, Tani-ichi S, Schlenner S, Richie E, Rodewald HR, Flavell RA, Nagasawa T, Ikuta K, Pereira JP. Hematopoietic stem cell niches produce lineage-instructive signals to control multipotent progenitor differentiation. Immunity, 45:1219-1231, 2016.
  8. Shinoda K, Hirahara K, Iinuma T, Ichikawa T, Suzuki AS, Sugaya K, Tumes DJ, Yamamoto H, Hara T, Tani-ichi S, Ikuta K, Okamoto Y, Nakayama T. Thy1+IL-7+ lymphatic endothelial cells in iBALT provide a survival niche for memory T-helper cells in allergic airway inflammation. Proc Natl Acad Sci USA, 113:E2842-2851, 2016.
  9. Abe A, Tani-ichi S, Shitara S, Cui G, Yamada H, Miyachi H, Kitano S, Hara T, Abe R, Yoshikai Y, and Ikuta K. An enhancer of the IL-7 receptor α-chain locus controls IL-7 receptor expression and maintenance of peripheral T cells. J Immunol, 195:3129-3138, 2015.
  10. Wagatsuma K*, Tani-ichi S*, Liang B, Shitara S, Ishihara K, Abe M, Miyachi H, Kitano S, Hara T, Nanno M, Ishikawa H, Sakimura K, Nakano M, Kimura H, and Ikuta K. STAT5 orchestrates local epigenetic changes for chromatin accessibility and rearrangements by direct binding to the TCRγ locus. J Immunol, 195: 1804-1814, 2015.
    *equal contribution.
  11. Tsuneto M, Kajikhina E, Seiler K, Reimer A, Tornack J, Bouquet C, Simmons S, Knoll M, Wolf I, Tokoyoda K, Hauser A, Hara T, Tani-ichi S, Ikuta K, Grun JR, Grutzkau A, Engels N, Wienands J, Yanagisawa Y, Ohnishi K, and Melchers F. Environments of B cell development. Immunol Lett, 157:60-63, 2014.
  12. Cui G, Hara T, Simmons S, Wagatsuma K, Abe A, Miyachi H, Kitano S, Ishii M, Tani-ichi S, and Ikuta K. Characterization of the interleukin-15 niche in primary and secondary lymphoid organs in vivo. Proc Natl Acad Sci USA, 111:1915-1920, 2014.
  13. Tsuneto M, Tokoyoda K, Kajikhina E, Hauser AE, Hara T, Tani-ichi S, Ikuta K, and Melchers F. B cell progenitors and precursors change their microenvironment in fetal liver during early development. Stem Cells, 31:2800-2812, 2013.
  14. Hanazawa A, Hayashizaki K, Shinoda K, Yagita H, Okumura K, Lohning M, Hara T, Tani-ichi S, Ikuta K, Eckes B, Radbruch A, Tokoyoda K, and Nakayama T. CD49b-dependent establishment of T helper cell memory. Immunol Cell Biol, 91:524-531, 2013.
  15. Shitara S, Hara T, Liang B, Wagatsuma K, Zuklys S, Hollander GA, Nakase H, Chiba T, Tani-ichi S, and Ikuta K. Interleukin-7 produced by thymic epithelial cells plays a major role in the development of thymocytes and TCRγδ+ intraepithelial lymphocytes. J Immunol, 190:6173-6179, 2013.
  16. Sekai M, Tani-ichi S, Yoneyama M, Fujita T, Kina T, and Ikuta K. Lymphocyte-stromal cell interaction induces IL-7 expression by interferon regulatory factors. Mol Immunol, 54:378-385, 2013.
  17. Tani-ichi S, Shimba A, Wagatsuma K, Miyachi H, Kitano S, Imai K, Hara T, and Ikuta K. The interleukin-7 receptor controls development and maturation of late stages of thymocyte subpopulations. Proc Natl Acad Sci USA, 110:612-617, 2013.
  18. Liang B, Hara T, Wagatsuma K, Zhang J, Maki K, Miyachi H, Kitano S, Yabe-Nishimura C, Tani-ichi S, and Ikuta K. Role of hepatocyte-derived IL-7 in maintenance of intrahepatic NK T and T cells and development of B cells in fetal liver. J Immunol, 189:4444-4450, 2012.
  19. Hara T, Shitara S, Imai K, Miyachi H, Kitano S, Yao H, Tani-ichi S, and Ikuta K. Identification of interleukin-7-producing cells in primary and secondary lymphoid organs using IL-7-GFP knock-in mice. J Immunol, 189:1577-1584, 2012.
  20. Tani-ichi S, Satake M, and Ikuta K. The pre-TCR signal induces transcriptional silencing of the TCRγ locus by reducing the recruitment of STAT5 and Runx to transcriptional enhancers. Int Immunol, 23:553-563, 2011.
  21. Tani-ichi S, Lee HC, Ye SK, and Ikuta K. Accessibility control of TCR Vγ region by STAT5. Int Immunol, 22: 693-703, 2010.
  22. Tani-ichi S, Satake M, and Ikuta K. Activation of the mouse T cell receptor γ enhancers by STAT5. Int Immunol, 21:1079-1088, 2009.
  23. Toda T, Wada H, Ogawa S, Tani-ichi S, and Ikuta K. An efficient reporter assay for Stat5-dependent promoters. Anal Biochem, 372:250-252, 2008.
  24. Masui N, Tani-ichi S, Maki K, and Ikuta K. Transcriptional activation of mouse TCR Jγ4 germline promoter by Stat5. Mol Immunol, 45:849-855, 2008.
  25. Shibata H, Tani-ichi S, Lee HC, Maki K, and Ikuta K. Induction of the IL-7 receptor α chain in mouse peripheral B cells by glucocorticoids. Immunol Lett, 111:45-50, 2007.
  26. Tani-ichi S, Maruyama K, Kondo N, Nagafuku M, Kabayama K, Inokuchi J, Shimada Y, Ohno-Iwashita Y, Yagita H, Kawano S, and Kosugi A. Structure and function of lipid rafts in human activated T cells. Int Immunol, 17:749-758, 2006.
  27. Nagafuku M, Kabayama K, Oka D, Kato A, Tani-ichi S, Shimada Y, Ohno-Iwashita Y, Yamasaki S, Saito T, Iwabuchi K, Hamaoka T, Inokuchi J, and Kosugi A. Reduction of glycosphingolipid levels in lipid rafts affects the expression state and function of glycosylphosphatidylinositol-anchored proteins but does not impair signal transduction via the T cell receptor. J Biol Chem, 278:51920-51927, 2003.
  28. Yasuda K, Nagafuku M, Shima T, Okada M, Yagi T, Yamada T, Minaki Y, Kato A, Tani-ichi S, Hamaoka T, Kosugi A. Fyn is essential for tyrosine phosphorylation of Csk-binding protein/phosphoprotein associated with glycolipid-enriched microdomains in lipid rafts in resting T cells. J Immunol, 169:2813-2817, 2002.

学術雑誌等又は商業誌における解説、総説

  1. エンハンサーによるIL-7レセプターの発現の制御
    生田宏一、阿部昌史、谷一靖江
    医学のあゆみ 257:1170-1172, 2016.
  2. 後期T細胞分化におけるIL-7Rの機能
    谷一靖江、生田宏一
    医学のあゆみ, 2014; 250(3), 226-227.
  3. T細胞におけるIL-7レセプターの転写制御と機能
    谷一靖江、原崇裕、生田宏一
    臨床免疫・アレルギー科, 2014; 61(4): 450-456.
  4. 肝臓IL-7の新たな機能
    生田宏一、原崇裕、谷一靖江
    感染 炎症 免疫, 2014; 198(43): 61-63.
  5. 胸腺上皮細胞が産生するサイトカインとT細胞の分化
    生田宏一、原崇裕、谷一靖江
    臨床免疫・アレルギー科, 2011; 56(3): 219-224.
  6. αβ T細胞レセプターとγδ T細胞レセプターの発現制御機構
    谷一靖江、生田宏一
    臨床免疫・アレルギー科, 2011; 56(3): 255-261.
  7. STAT5によるTCRγ遺伝子座の組換え制御機構
    生田宏一、谷一靖江
    医学のあゆみ, 2011; 237(13): 1181-1185.
  8. Role of the IL-7 receptor in γδ T-cell development from hematopoietic stem cells.
    Koichi Ikuta, Shizue Tani-ichi
    Hematopoietic Stem Cell Biology, Humana Press Inc., 2009; 143-159.
  9. クロマチン構造変換によるリンパ球抗原受容体遺伝子の組換え制御
    生田宏一、谷一靖江
    蛋白質 核酸 酵素, 2006; 51(14): 2102-2107.
  10. Raft (GEM)
    谷一靖江、小杉 厚
    医学のあゆみ, 2002; 200(13).
  11. RaftとT細胞活性化 Lipid raft and T cell activation
    谷一靖江、小杉 厚
    Medical Science Digest, 2002; 28: 4-5.